| Gene Symbol |
CRLS1
|
| Entrez Gene |
54675
|
| Alt Symbol |
C20orf155, CLS, CLS1, GCD10, dJ967N21.6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cardiolipin synthase 1
|
| Other Description |
cardiolipin synthase (CMP-forming)
|
| Swissprots |
Q69YQ5 E9PAT4 Q27RP0 D3DW09 Q9UJA2
|
| Accessions |
EAX10399 EAX10400 EAX10401 EAX10402 Q9UJA2 AF241784 AAG44472 AK310368 AL832419 CAH10649 BC069010 AAH69010 BM763234 BP368984 DQ386730 ABD46888 XM_005260737 XP_005260794 XM_005260738 XP_005260795 XM_006723579 XP_006723642 XM_006723580 XP_006723643 XM_011529262 XP_011527564 XM_011529263 XP_011527565 XM_011529264 XP_011527566 XM_011529265 XP_011527567 NM_001127458 NP_001120930 NM_019095 NP_061968
|
| Function |
Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. {ECO:0000269|PubMed:16547353, ECO:0000269|PubMed:16678169}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000269|PubMed:16547353}; Multi-pass membrane protein {ECO:0000269|PubMed:16547353}.
|
| Tissue Specificity |
Highly expressed in tissues such as heart, skeletal muscle and liver. {ECO:0000269|PubMed:16547353}.
|
| Top Pathways |
Glycerophospholipid metabolism
|