| Gene Symbol |
EIF3I
|
| Entrez Gene |
8668
|
| Alt Symbol |
EIF3S2, PRO2242, TRIP-1, TRIP1, eIF3-beta, eIF3-p36
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 3, subunit I
|
| Other Description |
TGF-beta receptor-interacting protein 1|TGFbeta receptor-interacting protein 1|eIF-3-beta|eIF3 p36|eukaryotic translation initiation factor 3 subunit 2|eukaryotic translation initiation factor 3 subunit I|eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)|eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa|predicted protein of HQ2242
|
| Swissprots |
Q13347
|
| Accessions |
EAX07552 EAX07553 EAX07554 EAX07555 Q13347 AF116697 AAF71117 AK130633 AK222483 BAD96203 AK225024 AK289356 BAF82045 AK289882 BAF82571 BC000413 AAH00413 BC003140 AAH03140 BC018815 BM761611 BT019597 AAV38404 DQ891249 ABM82175 DQ894600 ABM85526 U36764 AAC50224 U39067 AAC97144 XM_011542354 XP_011540656 XM_011542355 XP_011540657 NM_003757 NP_003748
|
| Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
|
| Top Pathways |
RNA transport
|