Gene Symbol | EIF3I |
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Entrez Gene | 8668 |
Alt Symbol | EIF3S2, PRO2242, TRIP-1, TRIP1, eIF3-beta, eIF3-p36 |
Species | Human |
Gene Type | protein-coding |
Description | eukaryotic translation initiation factor 3, subunit I |
Other Description | TGF-beta receptor-interacting protein 1|TGFbeta receptor-interacting protein 1|eIF-3-beta|eIF3 p36|eukaryotic translation initiation factor 3 subunit 2|eukaryotic translation initiation factor 3 subunit I|eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)|eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa|predicted protein of HQ2242 |
Swissprots | Q13347 |
Accessions | EAX07552 EAX07553 EAX07554 EAX07555 Q13347 AF116697 AAF71117 AK130633 AK222483 BAD96203 AK225024 AK289356 BAF82045 AK289882 BAF82571 BC000413 AAH00413 BC003140 AAH03140 BC018815 BM761611 BT019597 AAV38404 DQ891249 ABM82175 DQ894600 ABM85526 U36764 AAC50224 U39067 AAC97144 XM_011542354 XP_011540656 XM_011542355 XP_011540657 NM_003757 NP_003748 |
Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. |
Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}. |
Top Pathways | RNA transport |
Human EIF3S2 full length protein - ab171491 from Abcam
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Human EIF3S2 peptide - ab41639 from Abcam
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Human EIF3S2 peptide - ab41640 from Abcam
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EIF3I / EIF3S2 Antibody Blocking Peptide - LS-E23635 from LifeSpan Bioscience
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EIF3I / EIF3S2 Antibody Blocking Peptide - LS-E23636 from LifeSpan Bioscience
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TRIP1 Partial Recombinant Protein - H00008668-Q01 from Novus Biologicals
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TRIP1 Recombinant Protein - H00008668-P01 from Novus Biologicals
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Recombinant Human TRIP1 Protein - NBP2-23031 from Novus Biologicals
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EIF3S2 Recombinant Protein - GTX48110-PRO from GeneTex
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Recombinant human Eukaryotic translation initiation factor 3 subunit I protein (OPCA00494) - OPCA00494 from Aviva Systems Biology
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EIF3I / EIF3S2 (1-325, His-tag) - AR51214PU-N from Acris Antibodies
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EIF3I / EIF3S2 (1-325, His-tag) - AR51214PU-S from Acris Antibodies
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EIF3I / EIF3S2 - H00008668-P01-10 from Acris Antibodies
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EIF3I / EIF3S2 - H00008668-P01-25 from Acris Antibodies
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EIF3I / EIF3S2 - H00008668-Q01-10 from Acris Antibodies
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EIF3I / EIF3S2 - H00008668-Q01-25 from Acris Antibodies
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EIF3I, 1-325aa, Human, His tag, E.coli - 01-P2393 from ARP American Research Products
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EIF3S2 Recombinant Protein - XW-RP3072 from ProSci
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EIF3I fusion protein - ag1847 from Proteintech Group
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EIF3I fusion protein - ag18097 from Proteintech Group
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Recombinant Human EIF3G, T7-tagged - EIF3G-3064H from Creative Biomart
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Recombinant Human EIF3I, T7-tagged - EIF3I-1534H from Creative Biomart
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Recombinant Human eukaryotic translation initiation factor 3, subunit I, His-tagged - EIF3I-310H from Creative Biomart
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Recombinant Human Eukaryotic translation initiation factor 3 subunit I(EIF3I) - CSB-YP622652HU CSB-EP622652HU CSB-BP622652HU CSB-MP622652HU from Cusabio
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Recombinant Eukaryotic translation initiation factor 3 subunit I(eif-3.I) - CSB-YP007538CXX CSB-EP007538CXX CSB-BP007538CXX CSB-MP007538CXX from Cusabio
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