EIF3I

Gene Symbol EIF3I
Entrez Gene 8668
Alt Symbol EIF3S2, PRO2242, TRIP-1, TRIP1, eIF3-beta, eIF3-p36
Species Human
Gene Type protein-coding
Description eukaryotic translation initiation factor 3, subunit I
Other Description TGF-beta receptor-interacting protein 1|TGFbeta receptor-interacting protein 1|eIF-3-beta|eIF3 p36|eukaryotic translation initiation factor 3 subunit 2|eukaryotic translation initiation factor 3 subunit I|eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)|eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa|predicted protein of HQ2242
Swissprots Q13347
Accessions EAX07552 EAX07553 EAX07554 EAX07555 Q13347 AF116697 AAF71117 AK130633 AK222483 BAD96203 AK225024 AK289356 BAF82045 AK289882 BAF82571 BC000413 AAH00413 BC003140 AAH03140 BC018815 BM761611 BT019597 AAV38404 DQ891249 ABM82175 DQ894600 ABM85526 U36764 AAC50224 U39067 AAC97144 XM_011542354 XP_011540656 XM_011542355 XP_011540657 NM_003757 NP_003748
Function Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Subcellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
Top Pathways RNA transport

eIF3β siRNA (h) - sc-60080 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

eIF3β shRNA Plasmid (h) - sc-60080-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

eIF3β shRNA (h) Lentiviral Particles - sc-60080-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRIP1 RNAi - H00008668-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU136561 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7765 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7765 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03460 from Sigma-Aldrich

Category miRNA

EIF3I siRNA (Human) - CRH5703 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EIF3I - MBS8211088 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human EIF3I (NM_003757.2) - SHH284525 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human EIF3S2(NM_003757.2) - SHH029225 from Creative biogene

Category siRNA
Species Reactivities Human

EIF3I shRNA Plasmid (Human) - CHH5703 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EIF3I miRNA 3'UTR clone - MiUTR1H-03164 from Creative biogene

Species Reactivities Human
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