Gene Symbol | ATP6V0A2 |
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Entrez Gene | 23545 |
Alt Symbol | A2, ARCL, ARCL2A, ATP6A2, ATP6N1D, J6B7, RTF, STV1, TJ6, TJ6M, TJ6S, VPH1, WSS |
Species | Human |
Gene Type | protein-coding |
Description | ATPase, H+ transporting, lysosomal V0 subunit a2 |
Other Description | A2V-ATPase|V-type proton ATPase 116 kDa subunit a isoform 2|lysosomal H(+)-transporting ATPase V0 subunit a2|regeneration and tolerance factor|v-ATPase 116 kDa|v-type proton ATPase 116 kDa subunit a|vacuolar proton translocating ATPase 116 kDa subunit a |
Swissprots | Q6NUM0 A8K026 Q9Y487 |
Accessions | EAW98434 EAW98436 Q9Y487 AF112972 AAD04632 AK056800 AK289391 BAF82080 AK298778 BAG60919 BC000826 BC022300 AAH22300 BC068531 AAH68531 BG106215 BG167832 BG759946 BI562012 BQ050095 BX328381 CB960860 CD654920 DA737084 HQ258004 ADR82758 R51339 XM_005253563 XP_005253620 XM_006719317 XP_006719380 XM_006719318 XP_006719381 XR_429088 NM_012463 NP_036595 |
Function | Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. {ECO:0000269|PubMed:16415858, ECO:0000269|PubMed:18157129}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Endosome membrane. Note=In kidney proximal tubules, also detected in subapical vesicles. {ECO:0000250}. |
Top Pathways | Collecting duct acid secretion, Tuberculosis, Synaptic vesicle cycle, Rheumatoid arthritis, Phagosome |
V-ATPase A2 CRISPR/Cas9 KO Plasmid (h) - sc-406000 from Santa Cruz Biotechnology
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V-ATPase A2 HDR Plasmid (h) - sc-406000-HDR from Santa Cruz Biotechnology
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V-ATPase A2 Double Nickase Plasmid (h) - sc-406000-NIC from Santa Cruz Biotechnology
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V-ATPase A2 Double Nickase Plasmid (h2) - sc-406000-NIC-2 from Santa Cruz Biotechnology
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V-ATPase A2 CRISPR Activation Plasmid (h) - sc-406000-ACT from Santa Cruz Biotechnology
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V-ATPase A2 CRISPR Activation Plasmid (h2) - sc-406000-ACT-2 from Santa Cruz Biotechnology
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V-ATPase A2 Lentiviral Activation Particles (h) - sc-406000-LAC from Santa Cruz Biotechnology
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V-ATPase A2 Lentiviral Activation Particles (h2) - sc-406000-LAC-2 from Santa Cruz Biotechnology
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V-ATPase A2 siRNA (h) - sc-63201 from Santa Cruz Biotechnology
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V-ATPase A2 shRNA Plasmid (h) - sc-63201-SH from Santa Cruz Biotechnology
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V-ATPase A2 shRNA (h) Lentiviral Particles - sc-63201-V from Santa Cruz Biotechnology
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ATP6V0A2 RNAi - H00023545-R01 from Novus Biologicals
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MISSION® esiRNA - EHU078031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3718 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3718 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10645 from Sigma-Aldrich
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ATP6V0A2 siRNA (Human) - CRH8347 from Cohesion Biosciences
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ATP6V0A2 - MBS8230864 from MyBioSource
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shRNA set against Human ATP6V0A2 (NM_012463.3) - SHH242990 from Creative biogene
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Human ATP6V0A2 siRNA - orb268849 from Biorbyt
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ATP6V0A2 shRNA Plasmid (Human) - CHH8347 from Cohesion Biosciences
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ATP6V0A2 miRNA 3'UTR clone - MiUTR4H-TG00637 from Creative biogene
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