CNOT6

Gene Symbol	CNOT6
Entrez Gene	57472
Alt Symbol	CCR4, Ccr4a
Species	Human
Gene Type	protein-coding
Description	CCR4-NOT transcription complex, subunit 6
Other Description	CCR4-NOT transcription complex subunit 6|carbon catabolite repression 4 protein|carbon catabolite repressor protein 4 homolog|cytoplasmic deadenylase
Swissprots	D3DWR0 A7MD46 Q9ULM6
Accessions	CAD32417 EAW53752 EAW53753 EAW53754 Q9ULM6 AB033020 BAA86508 AI025725 AK023599 AK314752 BAG37291 AL110144 BC015331 BC027476 AAH27476 BC073142 BC090918 BC114958 BC152469 AAI52470 BC160174 AAI60174 BF940524 BM769589 BQ232180 D20789 DA370007 XM_005265953 XP_005266010 XM_011534605 XP_011532907 XM_011534606 XP_011532908 XM_011534607 XP_011532909 XM_011534608 XP_011532910 XM_011534609 XP_011532911 NM_001303241 NP_001290170 NM_015455
Function	Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein- coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence. {ECO:0000269|PubMed:11889047, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:21233283}.
Subcellular Location	Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CNOT6 (E1L8F) Rabbit mAb - 13415 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone E1L8F

CNOT6 (H-34) - sc-368367 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

CNOT6 (N-17) - sc-82831 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CNOT6 (W-18) - sc-82832 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CNOT6 (2193C2a) - sc-81231 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-CNOT6 antibody - ab187329 from Abcam Host Rabbit Clonality Polyclonal

Anti-CNOT6 antibody [2193C2a] - ab54376 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2193C2a

Anti-CNOT6 antibody - C-terminal - ab138770 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CNOT6 Antibody - LS-C78041 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-CNOT6 Antibody (clone 2193C2a) - LS-C184544 from LifeSpan Bioscience Prices $335.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 2193C2a

Anti-CNOT6 Antibody (aa415-442, APC) - LS-C234045 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CNOT6 Antibody (aa415-442, AP) - LS-C234046 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CNOT6 Antibody (aa415-442, Biotin) - LS-C234047 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CNOT6 Antibody (aa415-442, FITC) - LS-C234048 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CNOT6 Antibody (aa415-442, PE) - LS-C234049 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CNOT6 Antibody (aa112-211) - LS-C307007 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-CNOT6 Antibody (aa415-442, Azide-free, HRP) - LS-C249716 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CNOT6 Antibody (aa35-84) - LS-C101873 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CNOT6 Antibody (aa415-442) - LS-C320490 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CNOT6 Antibody (aa415-442) - LS-C159378 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-CNOT6 Antibody (clone 2193C2a) - LS-C342579 from LifeSpan Bioscience Prices $375.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2193C2a

CNOT6 Antibody - NBP1-57550 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CNOT6 Antibody - NBP1-86564 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CNOT6 Antibody (4A3) - H00057472-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4A3

CNOT6 Polyclonal Antibody - bs-9386R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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