PAXBP1
| Gene Symbol | PAXBP1 |
|---|---|
| Entrez Gene | 94104 |
| Alt Symbol | BM020, C21orf66, FSAP105, GCFC, GCFC1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | PAX3 and PAX7 binding protein 1 |
| Other Description | GC-rich sequence DNA-binding factor 1|GC-rich sequence DNA-binding factor candidate|PAX3- and PAX7-binding protein 1|functional spliceosome-associated protein 105 |
| Swissprots | D3DSE7 Q9Y5B6 Q96DU8 Q9NYQ0 |
| Accessions | EAX09857 EAX09858 EAX09859 EAX09860 EAX09861 Q9Y5B6 AF153208 AAD34617 AF208862 AAF64276 AF231920 AAF72944 AJ279080 CAC40813 AJ279081 CAC40814 AK075042 BAC11369 AK093291 BAG52682 AK128513 BAG54687 AK309404 AL706425 AY033903 AAK68721 AY033904 AAK68722 AY033905 AAK68723 AY033906 AAK68724 BC005213 BC030539 AAH30539 BC062992 BC084542 AAH84542 BC156214 AAI56215 CD557070 DB031308 DQ891624 ABM82550 DQ894815 ABM85741 XM_006724066 XP_006724129 XM_006724067 XP_006724130 XM_011529804 XP_011528106 XM_011529805 XP_011528107 NM_013329 NP_037461 NM_016631 NP_057715 NR_027873 NM_058191 NM_145328 |
| Function | Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with an histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:11707072}. |
GCFC1 CRISPR/Cas9 KO Plasmid (h) - sc-413995 from Santa Cruz Biotechnology
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GCFC1 HDR Plasmid (h) - sc-413995-HDR from Santa Cruz Biotechnology
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GCFC1 Double Nickase Plasmid (h) - sc-413995-NIC from Santa Cruz Biotechnology
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GCFC1 Double Nickase Plasmid (h2) - sc-413995-NIC-2 from Santa Cruz Biotechnology
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GCFC1 CRISPR Activation Plasmid (h) - sc-413995-ACT from Santa Cruz Biotechnology
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GCFC1 CRISPR Activation Plasmid (h2) - sc-413995-ACT-2 from Santa Cruz Biotechnology
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GCFC1 Lentiviral Activation Particles (h) - sc-413995-LAC from Santa Cruz Biotechnology
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GCFC1 Lentiviral Activation Particles (h2) - sc-413995-LAC-2 from Santa Cruz Biotechnology
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GCFC1 siRNA (h) - sc-91440 from Santa Cruz Biotechnology
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GCFC1 shRNA Plasmid (h) - sc-91440-SH from Santa Cruz Biotechnology
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GCFC1 shRNA (h) Lentiviral Particles - sc-91440-V from Santa Cruz Biotechnology
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GCFC1 RNAi - H00094104-R04 from Novus Biologicals
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GCFC1 RNAi - H00094104-R02 from Novus Biologicals
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GCFC1 RNAi - H00094104-R01 from Novus Biologicals
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MISSION® esiRNA - EHU084821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9184 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9184 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08296 from Sigma-Aldrich
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PAXBP1 siRNA (Human) - CRJ4251 from Cohesion Biosciences
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GCFC1 RNAi - H00094104-R03 from Novus Biologicals
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shRNA set against Human GCFC1 (NM_013329.3) - SHH299966 from Creative biogene
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shRNA set against Human C21orf66(NM_013329.3) - SHG121393 from Creative biogene
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shRNA set against Human C21orf66(NM_016631.3) - SHG121645 from Creative biogene
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PAXBP1 shRNA Plasmid (Human) - CHJ4251 from Cohesion Biosciences
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GCFC1 miRNA 3'UTR clone - MiUTR1H-01349 from Creative biogene
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