| Gene Symbol | PXYLP1 |
|---|---|
| Entrez Gene | 92370 |
| Alt Symbol | ACPL2, HEL124, XYLP |
| Species | Human |
| Gene Type | protein-coding |
| Description | 2-phosphoxylose phosphatase 1 |
| Other Description | acid phosphatase-like 2|acid phosphatase-like protein 2|epididymis luminal protein 124|xylosyl phosphatase |
| Swissprots | Q8TE99 D3DNF5 W0TR04 Q49AJ2 |
| Accessions | EAW79007 EAW79008 EAW79009 Q8TE99 AB827640 BAO45795 AK074331 BAB85053 AK296292 BAH12305 AK297790 BAH12668 AK316121 BAH14492 AL137529 CAB70793 AY358460 AAQ88825 BC035834 AAH35834 BC036701 AAH36701 BX647621 CA421956 CD101677 CX762355 DC409719 EU794677 ACJ13731 XM_005247903 XP_005247960 XM_011513314 XP_011511616 XM_011513315 XP_011511617 XM_011513316 XP_011511618 NM_001037172 NP_001032249 NM_001282728 NP_001269657 NM_152282 NP_689495 |
| Function | Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1- 4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. {ECO:0000269|PubMed:24425863}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000269|PubMed:24425863}; Single-pass type II membrane protein {ECO:0000255}. Note=Colocalizes to Golgi apparatus in a B3GAT3-dependent manner. {ECO:0000269|PubMed:24425863}. |
| Tissue Specificity | Widely expressed. Strongly expressed in spleen, fetal liver, moderately in placenta, pancreas, kidney, thymus and colon. {ECO:0000269|PubMed:24425863}. |
ACPL2 CRISPR/Cas9 KO Plasmid (h) - sc-410236 from Santa Cruz Biotechnology
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ACPL2 HDR Plasmid (h) - sc-410236-HDR from Santa Cruz Biotechnology
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ACPL2 Double Nickase Plasmid (h) - sc-410236-NIC from Santa Cruz Biotechnology
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ACPL2 Double Nickase Plasmid (h2) - sc-410236-NIC-2 from Santa Cruz Biotechnology
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ACPL2 CRISPR Activation Plasmid (h) - sc-410236-ACT from Santa Cruz Biotechnology
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ACPL2 CRISPR Activation Plasmid (h2) - sc-410236-ACT-2 from Santa Cruz Biotechnology
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ACPL2 Lentiviral Activation Particles (h) - sc-410236-LAC from Santa Cruz Biotechnology
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ACPL2 Lentiviral Activation Particles (h2) - sc-410236-LAC-2 from Santa Cruz Biotechnology
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ACPL2 siRNA (h) - sc-78198 from Santa Cruz Biotechnology
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ACPL2 shRNA Plasmid (h) - sc-78198-SH from Santa Cruz Biotechnology
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ACPL2 shRNA (h) Lentiviral Particles - sc-78198-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU134651 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0015 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0013 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0916 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0014 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0915 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2741 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2741 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12642 from Sigma-Aldrich
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ACPL2 siRNA (Human) - CRJ4138 from Cohesion Biosciences
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ACPL2 - MBS8217747 from MyBioSource
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shRNA set against Human ACPL2 (NM_152282.3) - SHH230598 from Creative biogene
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shRNA set against Human ACPL2(NM_001037172.1) - SHG030853 from Creative biogene
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ACPL2 shRNA Plasmid (Human) - CHJ4138 from Cohesion Biosciences
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