Gene Symbol | TRPC3 |
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Entrez Gene | 7222 |
Alt Symbol | TRP3 |
Species | Human |
Gene Type | protein-coding |
Description | transient receptor potential cation channel, subfamily C, member 3 |
Other Description | hTrp-3|short transient receptor potential channel 3|transient receptor potential cation channel subfamily C member 3 variant c|transient receptor protein 3 |
Swissprots | O00593 E9PCJ9 Q13507 A7VJS1 Q52M35 Q15660 Q5G1L5 |
Accessions | AAY40971 CAJ01297 EAX05243 Q13507 AB255423 BAF76423 AB255424 BAF76424 AY865574 AAW62292 BC093682 AAH93682 BC093684 AAH93684 BC143239 KC207570 AGG20159 X89068 CAA61448 Y13758 CAA74083 XM_011532217 XP_011530519 XM_011532218 XP_011530520 XM_011532219 XP_011530521 NM_001130698 NP_001124170 NM_003305 NP_003296 |
Function | Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. {ECO:0000269|PubMed:20095964, ECO:0000269|PubMed:8646775, ECO:0000269|PubMed:9417057, ECO:0000269|PubMed:9930701}. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis. |
Human TRPC3 peptide - ab96636 from Abcam
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Human TRPC3 protein fragment - ab152769 from Abcam
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TRPC3 peptide - ab75651 from Abcam
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TRPC3 Antibody Blocking Peptide - LS-E3403 from LifeSpan Bioscience
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TRPC3 Antibody Blocking Peptide - LS-E30262 from LifeSpan Bioscience
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TRPC3 Antibody Blocking Peptide - LS-E30267 from LifeSpan Bioscience
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Recombinant Human TRPC3 Protein - H00007222-Q01 from Novus Biologicals
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TRPC3 Blocking Peptide - NBP1-77262PEP from Novus Biologicals
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TRPC3 Blocking Peptide - NBP1-76722PEP from Novus Biologicals
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TRPC3-Antibody-C-term-Blocking-Peptide - BP14579b from Abgent, a WuXi AppTec company
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TRPC3 Blocking Peptide - 33R-5923 from Fitzgerald
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TRPC3 / TRP3 - H00007222-Q01-10 from Acris Antibodies
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TRPC3 / TRP3 - H00007222-Q01-25 from Acris Antibodies
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TRPC3 / TRP3 Control Peptide - AP30954CP-N from Acris Antibodies
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TRPC3 / TRP3 Control Peptide - AP30955CP-N from Acris Antibodies
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TRPC3 Peptide - 3895P from ProSci
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TRPC3 Peptide - 8269P from ProSci
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TRPC3 Peptide - 3905P from ProSci
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TRPC3 fusion protein - ag13024 from Proteintech Group
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hTRPC3-HEK293 Recombinant Cell line - GWB-PS9311 from Genway Biotech
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TRPC3 Peptide - abx164825 from Abbexa
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TRPC3 / TRP3 (transcript variant 2) - TP310794 from Acris Antibodies
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TRPC3 Recombinant Protein Antigen - NBP1-86266PEP from Novus Biologicals
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TRPC3 Peptide, Human - M34GP16672H from Creative Peptides
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Short transient receptor potential channel 3 (TRPC3), Recombinant Protein - MBS7073766 from MyBioSource
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