DCP2

Gene Symbol DCP2
Entrez Gene 167227
Alt Symbol NUDT20
Species Human
Gene Type protein-coding
Description decapping mRNA 2
Other Description DCP2 decapping enzyme homolog|hDpc|m7GpppN-mRNA hydrolase|mRNA-decapping enzyme 2|nudix (nucleoside diphosphate linked moiety X)-type motif 20
Swissprots Q6P2D4 C9J778 Q7Z5W5 Q8IU60 Q8NBG5
Accessions EAW48988 EAW48989 EAW48990 EAW48991 EAW48992 Q8IU60 AA837315 AB002445 AK025019 AK090564 BAC03479 AK296361 BAH12331 AK311298 AL135390 AY135173 AAN08884 AY146650 AAN62762 BC017965 BC045596 AAH45596 BC064593 AAH64593 BC068042 BG720562 BX537716 BX648838 CF994730 DB146225 HQ448087 ADQ32568 XM_005271914 XP_005271971 NM_001242377 NP_001229306 NM_152624 NP_689837 NR_038352
Function Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. {ECO:0000269|PubMed:12218187, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:12486012, ECO:0000269|PubMed:12923261, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21070968}.
Subcellular Location Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB). A minor amount is nuclear.
Tissue Specificity Expressed in brain and testis. Not detected in heart (at protein level). {ECO:0000269|PubMed:21070968}.
Top Pathways RNA degradation

hDcp2 (H-146) - sc-368179 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

hDcp2 (N-18) - sc-26084 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

hDcp2 (S-19) - sc-26085 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

hDcp2 (V-25) - sc-133650 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
hDcp2 (V-25): sc-133650. Western blot analysis of hDcp2 expression in Jurkat whole cell lysate.

Anti-Dcp2 antibody - ab28658 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab28658 stained human HeLa cells. The cells were PFA fixed (10 min), permabilised in TBS-T (20 min) and incubated with the antibody (ab28658, 1µg/ml) for 1h at room temperature. 1%BSA / 10% normal goat serum / 0.3M glycine was used to quench autofluorescence and block non-specific protein-protein interactions. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red). DAPI was used to stain the cell nuclei (blue).

Anti-Dcp2 antibody - ab139718 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of Dcp2 in Human testis tissue with ab139718 at 20 ug/mL.

Anti-Dcp2 antibody - ab127185 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Dcp2 antibody (ab127185) at 1/1000 dilution + IMR32 whole cell lysate at 30 µg

Anti-Dcp2 antibody - ab168574 from Abcam

Host Mouse
Clonality Polyclonal
All lanes : Anti-Dcp2 antibody (ab168574) at 1 µg/mlLane 1 : Lysate from 293T cells transfected with Dcp2Lane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-Dcp2 antibody - C-terminal - ab189966 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of formalin-fixed, paraffin-embedded Human small intestine tissue labeling Dcp2 with ab189966 at 10 µg/ml.

Anti-DCP2 Antibody (aa144-173, PE) - LS-C208777 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DCP2 Antibody (aa370-420) - LS-C289330 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DCP2 Antibody - LS-C307190 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-DCP2 Antibody (aa151-181) - LS-C320764 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DCP2 Antibody (aa144-173) - LS-C167299 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
DCP2 Antibody IHC of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-DCP2 Antibody IHC-plus™ - LS-B9375 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-DCP2 Antibody (C-Terminus) IHC-plus™ - LS-B8872 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-DCP2 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-DCP2 Antibody (aa265-314) - LS-C82442 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Jurkat cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.

Anti-DCP2 Antibody (aa144-173, AP) - LS-C208770 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DCP2 Antibody (aa324-373) - LS-C110609 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DCP2 antibody LS-C110609 Western blot of Placenta lysate.

Anti-DCP2 Antibody (aa144-173, APC) - LS-C208772 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DCP2 Antibody (aa144-173, Biotin) - LS-C208773 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DCP2 Antibody (aa144-173, FITC) - LS-C208774 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DCP2 Antibody (aa144-173, Azide-free, HRP) - LS-C208775 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DCP2 Antibody - LS-C136941 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DCP2 Antibody - NBP1-57441 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DCP2 Antibody [NBP1-57441] - Human Placenta lysate, concentration 0.2-1 ug/ml.
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