| Gene Symbol |
DCP2
|
| Entrez Gene |
167227
|
| Alt Symbol |
NUDT20
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
decapping mRNA 2
|
| Other Description |
DCP2 decapping enzyme homolog|hDpc|m7GpppN-mRNA hydrolase|mRNA-decapping enzyme 2|nudix (nucleoside diphosphate linked moiety X)-type motif 20
|
| Swissprots |
Q6P2D4 C9J778 Q7Z5W5 Q8IU60 Q8NBG5
|
| Accessions |
EAW48988 EAW48989 EAW48990 EAW48991 EAW48992 Q8IU60 AA837315 AB002445 AK025019 AK090564 BAC03479 AK296361 BAH12331 AK311298 AL135390 AY135173 AAN08884 AY146650 AAN62762 BC017965 BC045596 AAH45596 BC064593 AAH64593 BC068042 BG720562 BX537716 BX648838 CF994730 DB146225 HQ448087 ADQ32568 XM_005271914 XP_005271971 NM_001242377 NP_001229306 NM_152624 NP_689837 NR_038352
|
| Function |
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. {ECO:0000269|PubMed:12218187, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:12486012, ECO:0000269|PubMed:12923261, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21070968}.
|
| Subcellular Location |
Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB). A minor amount is nuclear.
|
| Tissue Specificity |
Expressed in brain and testis. Not detected in heart (at protein level). {ECO:0000269|PubMed:21070968}.
|
| Top Pathways |
RNA degradation
|
