DCP2

Gene Symbol	DCP2
Entrez Gene	167227
Alt Symbol	NUDT20
Species	Human
Gene Type	protein-coding
Description	decapping mRNA 2
Other Description	DCP2 decapping enzyme homolog|hDpc|m7GpppN-mRNA hydrolase|mRNA-decapping enzyme 2|nudix (nucleoside diphosphate linked moiety X)-type motif 20
Swissprots	Q6P2D4 C9J778 Q7Z5W5 Q8IU60 Q8NBG5
Accessions	EAW48988 EAW48989 EAW48990 EAW48991 EAW48992 Q8IU60 AA837315 AB002445 AK025019 AK090564 BAC03479 AK296361 BAH12331 AK311298 AL135390 AY135173 AAN08884 AY146650 AAN62762 BC017965 BC045596 AAH45596 BC064593 AAH64593 BC068042 BG720562 BX537716 BX648838 CF994730 DB146225 HQ448087 ADQ32568 XM_005271914 XP_005271971 NM_001242377 NP_001229306 NM_152624 NP_689837 NR_038352
Function	Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. {ECO:0000269|PubMed:12218187, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:12486012, ECO:0000269|PubMed:12923261, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21070968}.
Subcellular Location	Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB). A minor amount is nuclear.
Tissue Specificity	Expressed in brain and testis. Not detected in heart (at protein level). {ECO:0000269|PubMed:21070968}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Dcp2 full length protein - ab132368 from Abcam Category Protein Source Wheat germ Species Human

Human Dcp2 peptide - ab30458 from Abcam Category Peptide

DCP2 Antibody Blocking Peptide - LS-E31340 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DCP2 Antibody Blocking Peptide - LS-E9990 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DCP2 Antibody Blocking Peptide - LS-E15115 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DCP2 Antibody Blocking Peptide - LS-E15116 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DCP2 Protein - H00167227-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DCP2-Antibody-Center-Blocking-Peptide - BP9182c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human DCP2 protein - orb246177 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human DCP2 protein - orb244879 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

DCP2 Blocking Peptide - 33R-9500 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DCP2 Blocking Peptide - 33R-4618 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DCP2 - H00167227-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DCP2 - H00167227-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DCP2 (C-term) Control Peptide - AP55470CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

DCP2 Peptide - 7049P from ProSci Category Peptide Species Human

DCP2 fusion protein - Ag12727 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

DCP2 fusion protein - ag12001 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human DCP2, His-tagged - DCP2-11861H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant human m7GpppN-mRNA hydrolase - CSB-EP810265HU CSB-BP810265HU CSB-MP810265HU from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human mRNA-decapping enzyme 2(DCP2) - CSB-YP810265HU CSB-BP810265HU CSB-MP810265HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant Human mRNA-decapping enzyme 2(DCP2) - CSB-EP810265HU from Cusabio Category Protein Source Yeast Species Human

DCP2 Protein - abx163586 from Abbexa Category Protein Species Human, Rat

DCP2 Peptide, Human - M34GP04092H from Creative Peptides Category Peptide Source Synthetic. Species Human

DCP2 Recombinant Protein (OPCA02346) - OPCA02346 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

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