| Gene Symbol | DYNC1I2 |
|---|---|
| Entrez Gene | 1781 |
| Alt Symbol | DNCI2, IC2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | dynein, cytoplasmic 1, intermediate chain 2 |
| Other Description | DH IC-2|cytoplasmic dynein 1 intermediate chain 2|dynein intermediate chain 2, cytosolic|dynein, cytoplasmic, intermediate polypeptide 2 |
| Swissprots | Q7Z4X1 D3DPD5 Q5BJF8 Q32LY9 Q13409 Q96NG7 B7ZA04 Q9NT58 Q96S87 Q9BXZ5 D3DPD4 Q53S84 D3DPD6 |
| Accessions | AAX93177 AAY24133 EAX11199 EAX11200 EAX11201 EAX11202 EAX11203 EAX11204 EAX11205 EAX11206 EAX11207 EAX11208 EAX11209 Q13409 AB209014 BAD92251 AF134477 AAP97254 AF250307 AAK37426 AK024742 AK026574 BAB15502 AK055491 BAB70932 AK096579 AK225759 AK298561 BAG60755 AK301866 BAG63305 AK308008 AK316119 BAH14490 AL137519 CAB70785 AL832832 AM393760 CAL38635 AY037160 AAK67638 BC015038 AAH15038 BC091498 AAH91498 BC109375 AAI09376 BT007130 AAP35794 BX537412 CAD97654 DA435365 DQ786313 DQ786324 U39575 AAA89166 XM_005246363 XP_005246420 XM_005246364 XP_005246421 XM_005246365 XP_005246422 XM_005246366 XP_005246423 XM_005246367 XP_005246424 XM_005246369 XP_005246426 XM_006712347 XP_006712410 XM_006712348 XP_006712411 NM_001271785 NP_001258714 NM_001271786 NP_001258715 NM_001271787 NP_001258716 NM_001271788 NP_001258717 NM_001271789 NP_001258718 NM_001271790 NP_001258719 NM_001378 NP_001369 |
| Function | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. |
| Top Pathways | Vasopressin-regulated water reabsorption, Phagosome, Salmonella infection |