YBX2

Gene Symbol YBX2
Entrez Gene 51087
Alt Symbol CONTRIN, CSDA3, DBPC, MSY2
Species Human
Gene Type protein-coding
Description Y box binding protein 2
Other Description DNA-binding protein C|MSY2 homolog|Y-box-binding protein 2|germ cell specific Y-box binding protein|germ cell-specific Y-box-binding protein
Swissprots Q8N4P0 D3DTP1 Q9Y2T7
Accessions EAW90223 EAW90224 EAW90225 Q9Y2T7 AB208818 BAD92055 AF096834 AAD30662 AI805280 AK092747 AK315035 BAG37519 BC033800 AAH33800 BC047760 AAH47760 DB065912 NM_015982 NP_057066
Function Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:16479255}. Nucleus {ECO:0000269|PubMed:16479255}.
Tissue Specificity Expressed in oocytes and testicular germ cells in the stage of spermatogonia to spermatocyte. Also observed placental trophoblasts, as well as in vascular smooth muscle cells in the pulmonary artery, myocardium, and skeletal muscle. Undetectable in epithelial cells in respiratory, gastrointestinal, and urogenital tracts. Up-regulated in various carcinomas and germ cell tumors (at protein level). {ECO:0000269|PubMed:10100484, ECO:0000269|PubMed:16479255}.

MSY2 (C-15) - sc-21316 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MSY2 (C-15): sc-21316. Western blot analysis of MSY2 expression in non-transfected: sc-117752 (A) and human MSY2 transfected: sc-115033 (B) 293T whole cell lysates.

pan MSY (F-14) - sc-21315 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MSY2 (C-13) - sc-21321 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MSY2 (C-13): sc-21321. Western blot analysis of MSY2 expression in rat testis (A) and mouse testis (B) tissue extracts.

Anti-MSY2/YBOX2 antibody - ab33164 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab33164 stained F9 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab33164 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-MSY2/YBOX2 antibody - ab105336 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of MSY2/YBOX2 in Human testis tissue with ab105336 at 20 ug/mL.

Anti-MSY2/YBOX2 antibody - ab82963 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MSY2/YBOX2 antibody (ab82963) at 1 µg/ml + fetal lung lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-MSY2/YBOX2 antibody - ab80387 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab80387, at 1/10 dilution, staining MSY2/YBOX2 in formalin fixed, paraffin embedded human testis tissue by Immunohistochemistry. A peroxidase conjugated secondary antibody was used, followed by DAB staining.

Anti-MSY2/YBOX2 antibody - ab28643 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Human kidney tissue stained with ab28643 at 4 µg/ml. The arrows point to the epithelial cells of the renal tubule [positive label] (400X magnification).

Anti-MSY2/YBOX2 antibody - ab64906 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MSY2/YBOX2 antibody (ab64906) at 1/500 dilutionLane 1 : extracts from COLO205 cellsLane 2 : extracts from COLO205 cells with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-MSY2/YBOX2 antibody - ab71035 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MSY2/YBOX2 antibody (ab71035) at 1/60 dilution + Jurkat cell line lysates at 35 µg

Anti-MSY2/YBOX2 antibody [EPR2814(2)] - ab154829 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2814(2)
All lanes : Anti-MSY2/YBOX2 antibody [EPR2814(2)] (ab154829) at 1/1000 dilutionLane 1 : Human seminoma lysateLane 2 : Mouse testis lysateLane 3 : Rat testis lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-MSY2 / YBX2 Antibody (aa178-227) - LS-C30875 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
YBX2 antibody LS-C30875 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-MSY2 / YBX2 Antibody (AP) - LS-C284374 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MSY2 / YBX2 Antibody (aa36-85) - LS-C101499 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
YBX2 antibody LS-C101499 Western blot of Fetal Lung lysate.

Anti-MSY2 / YBX2 Antibody (APC) - LS-C284375 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MSY2 / YBX2 Antibody (FITC) - LS-C284376 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MSY2 / YBX2 Antibody (aa231-260) - LS-C98113 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-YBX2 Antibody (RB13983) in Jurkat cell line lysates (35 ug/lane). YBX2(arrow) was detected using the purified antibody.

Anti-MSY2 / YBX2 Antibody (Azide-free, HRP) - LS-C284377 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MSY2 / YBX2 Antibody (C-Terminus, AP) - LS-C284378 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MSY2 / YBX2 Antibody (C-Terminus, APC) - LS-C284379 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MSY2 / YBX2 Antibody (PE) - LS-C284380 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MSY2 / YBX2 Antibody (C-Terminus, Biotin) - LS-C284381 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MSY2 / YBX2 Antibody (aa294-323) - LS-C98112 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human testis tissue reacted with YBX2 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-MSY2 / YBX2 Antibody (C-Terminus, FITC) - LS-C284382 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MSY2 / YBX2 Antibody (Gly311) - LS-C176843 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of MSY2 (G311) pAb in extracts from COLO205 cells.
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