| Gene Symbol | NUDT21 |
|---|---|
| Entrez Gene | 11051 |
| Alt Symbol | CFIM25, CPSF5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nudix (nucleoside diphosphate linked moiety X)-type motif 21 |
| Other Description | CPSF 25 kDa subunit|cleavage and polyadenylation specific factor 5, 25 kD subunit|cleavage and polyadenylation specific factor 5, 25 kDa|cleavage and polyadenylation specificity factor 25 kDa subunit|cleavage and polyadenylation specificity factor subunit 5|cleavage factor Im complex 25 kDa subunit|nucleoside diphosphate-linked moiety X motif 21|nudix motif 21|pre-mRNA cleavage factor Im (25kD)|pre-mRNA cleavage factor Im 25 kDa subunit|pre-mRNA cleavage factor Im, 25kD subunit |
| Swissprots | Q6NE84 Q6IB85 O43809 |
| Accessions | EAW82859 EAW82860 O43809 AJ001810 CAA05026 AK312721 BAG35595 AL535307 AM392991 CAL37869 AM393219 CAL38097 BC001403 AAH01403 BX537360 CAD97606 BX647665 CAI46057 CR456919 CAG33200 DQ892142 ABM83068 DQ895336 ABM86262 NM_007006 NP_008937 |
| Function | Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export. {ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:20479262, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:9659921}. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles. |
| Top Pathways | mRNA surveillance pathway |
NUDT21 CRISPR/Cas9 KO Plasmid (h) - sc-402082 from Santa Cruz Biotechnology
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NUDT21 HDR Plasmid (h) - sc-402082-HDR from Santa Cruz Biotechnology
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NUDT21 Double Nickase Plasmid (h) - sc-402082-NIC from Santa Cruz Biotechnology
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NUDT21 Double Nickase Plasmid (h2) - sc-402082-NIC-2 from Santa Cruz Biotechnology
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NUDT21 CRISPR Activation Plasmid (h) - sc-402082-ACT from Santa Cruz Biotechnology
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NUDT21 CRISPR Activation Plasmid (h2) - sc-402082-ACT-2 from Santa Cruz Biotechnology
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NUDT21 Lentiviral Activation Particles (h) - sc-402082-LAC from Santa Cruz Biotechnology
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NUDT21 Lentiviral Activation Particles (h2) - sc-402082-LAC-2 from Santa Cruz Biotechnology
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NUDT21 siRNA (h) - sc-93336 from Santa Cruz Biotechnology
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NUDT21 shRNA Plasmid (h) - sc-93336-SH from Santa Cruz Biotechnology
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NUDT21 shRNA (h) Lentiviral Particles - sc-93336-V from Santa Cruz Biotechnology
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NUDT21 RNAi - H00011051-R01 from Novus Biologicals
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MISSION® esiRNA - EHU041141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15600 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15600 from Sigma-Aldrich
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NUDT21 siRNA (Human) - CRH7551 from Cohesion Biosciences
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shRNA set against Human NUDT21 (NM_007006.2) - SHH356160 from Creative biogene
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shRNA set against Human NUDT21(NM_007006.2) - SHR025904 from Creative biogene
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Human NUDT21 siRNA - orb268053 from Biorbyt
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NUDT21 shRNA Plasmid (Human) - CHH7551 from Cohesion Biosciences
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NUDT21 miRNA 3'UTR clone - MiUTR1H-06970 from Creative biogene
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