| Gene Symbol | ATP2B2 |
|---|---|
| Entrez Gene | 491 |
| Alt Symbol | PMCA2, PMCA2a, PMCA2i |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATPase, Ca++ transporting, plasma membrane 2 |
| Other Description | plasma membrane Ca(2+)-ATPase|plasma membrane Ca2+ pump 2|plasma membrane calcium ATPase|plasma membrane calcium pump|plasma membrane calcium-transporting ATPase 2 |
| Swissprots | Q12994 Q16818 O00766 Q01814 |
| Accessions | CAP58599 EAW64079 EAW64080 EAW64081 EAW64082 EAW64083 EAW64084 Q01814 AA197323 AB210008 BAE06090 AK308898 AL134596 BC019853 BC128575 BX489007 CA391502 CK023951 DQ201777 ABG24241 DQ201778 ABG24242 L00620 AAA51893 L20977 AAA50877 M97260 AAA36456 R53305 S95738 AAA08378 S95743 AAA08377 S95758 AAA08376 U15688 AAA60985 X63575 CAA45131 XM_005265179 XP_005265236 XM_006713175 XP_006713238 XM_011533751 XP_011532053 XM_011533752 XP_011532054 XM_011533753 XP_011532055 XM_011533754 XP_011532056 XM_011533755 XP_011532057 XM_011533756 XP_011532058 XM_011533757 XP_011532059 XM_011533758 XP_011532060 XM_011533759 XP_011532061 NM_001001331 NP_001001331 NM_001683 NP_001674 |
| Function | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. |
| Subcellular Location | Cell junction, synapse {ECO:0000250|UniProtKB:Q9R0K7}. Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. |
| Tissue Specificity | Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are found at low levels in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal muscle and heart muscle. |
| Top Pathways | Calcium signaling pathway, Salivary secretion, Pancreatic secretion, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway |