STRAP

Gene Symbol STRAP
Entrez Gene 11171
Alt Symbol MAWD, PT-WD, UNRIP
Species Human
Gene Type protein-coding
Description serine/threonine kinase receptor associated protein
Other Description MAP activator with WD repeats|WD-40 repeat protein PT-WD|serine-threonine kinase receptor-associated protein|unr-interacting protein
Swissprots B4DNJ6 Q9NTK0 B2R5S5 Q5TZT4 Q9UQC8 Q9Y3F4
Accessions EAW96356 Q9Y3F4 AB024327 BAA75544 AF161496 AAF29111 AJ010025 CAB38041 AK297942 BAG60258 AK312295 BAG35222 AK315891 BAF98782 AL136691 CAB66626 AY049776 AAL15433 BC000162 AAH00162 BC062306 AAH62306 BT020044 AAV38847 BT020045 AAV38848 DA666505 DQ890951 ABM81877 DQ894113 ABM85039 U56430 XM_005253294 XP_005253351 NM_007178 NP_009109
Function The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylatio
Subcellular Location Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the nucleus.
Top Pathways RNA transport

Human Unrip full length protein - ab132509 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE analysis of ab132509 stained with Coomassie Blue.

STRAP-Antibody-Center-Blocking-Peptide - BP2933c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

STRAP-Antibody-C-term-Blocking-Peptide - BP2933b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

STRAP - H00011171-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

STRAP - H00011171-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

STRAP fusion protein - Ag13085 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

Recombinant Human STRAP, His-tagged - STRAP-31671TH from Creative Biomart

Category Protein
Source E. coli

Recombinant Human STRAP, His-tagged - STRAP-3020H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Serine-threonine kinase receptor-associated protein(STRAP) - CSB-YP896713HU CSB-EP896713HU CSB-BP896713HU CSB-MP896713HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

STRAP - TP309149 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
STRAP

Human STRAP protein - orb54366 from Biorbyt

Category Protein
Prices $289.00, $408.00, $476.00, $765.00, $1,275.00, $2,023.00
Sizes 10 μg, 50 μg, 100 μg, 200 μg, 500 μg, 1 mg
Species Human

Serine-threonine kinase receptor-associated protein (STRAP), Recombinant Protein - MBS1337882 from MyBioSource

Category Protein
Prices $1,115.00, $1,115.00, $1,345.00, $1,345.00, $1,765.00, $1,765.00, $2,230.00, $2,230.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

STRAP Recombinant Protein (Human) (OPCA04853) - OPCA04853 from Aviva Systems Biology

Category Protein
Species Human
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