Gene Symbol | GNG4 |
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Entrez Gene | 2786 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | guanine nucleotide binding protein (G protein), gamma 4 |
Other Description | guanine nucleotide binding protein 4|guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 |
Swissprots | P50150 |
Accessions | CBX47432 CBX47433 CBX47434 EAW70030 EAW70031 P50150 AF493872 AAM12586 AK074383 AK311781 BAG34724 AL832564 BC022485 AAH22485 CX784976 DA122711 DA230013 DB501745 U31382 AAC50204 XM_006711761 XP_006711824 XM_011544165 XP_011542467 XM_011544166 XP_011542468 XM_011544167 XP_011542469 XM_011544168 XP_011542470 NM_001098721 NP_001092191 NM_001098722 NP_001092192 NM_004485 NP_004476 |
Function | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. |
Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. |
Tissue Specificity | Brain, kidney, pancreas, skeletal muscle and faintly in cardiac muscle. |
Top Pathways | Dopaminergic synapse, Morphine addiction, Glutamatergic synapse, PI3K-Akt signaling pathway, GABAergic synapse |
G γ 4 CRISPR/Cas9 KO Plasmid (h) - sc-418117 from Santa Cruz Biotechnology
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G γ 4 HDR Plasmid (h) - sc-418117-HDR from Santa Cruz Biotechnology
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G γ 4 Double Nickase Plasmid (h) - sc-418117-NIC from Santa Cruz Biotechnology
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G γ 4 Double Nickase Plasmid (h2) - sc-418117-NIC-2 from Santa Cruz Biotechnology
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G γ 4 CRISPR Activation Plasmid (h) - sc-418117-ACT from Santa Cruz Biotechnology
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G γ 4 CRISPR Activation Plasmid (h2) - sc-418117-ACT-2 from Santa Cruz Biotechnology
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G γ 4 Lentiviral Activation Particles (h) - sc-418117-LAC from Santa Cruz Biotechnology
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G γ 4 Lentiviral Activation Particles (h2) - sc-418117-LAC-2 from Santa Cruz Biotechnology
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G γ 4 siRNA (h) - sc-45433 from Santa Cruz Biotechnology
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G γ 4 shRNA Plasmid (h) - sc-45433-SH from Santa Cruz Biotechnology
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G γ 4 shRNA (h) Lentiviral Particles - sc-45433-V from Santa Cruz Biotechnology
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G gamma4 RNAi - H00002786-R02 from Novus Biologicals
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G gamma4 RNAi - H00002786-R01 from Novus Biologicals
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MISSION® esiRNA - EHU051761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9429 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9429 from Sigma-Aldrich
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GNG4 siRNA (Human) - CRH1858 from Cohesion Biosciences
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G gamma4 RNAi - H00002786-R03 from Novus Biologicals
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GNG4 - MBS8235313 from MyBioSource
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shRNA set against Human GNG4 (NM_004485.3) - SHH304906 from Creative biogene
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shRNA set against Human GNG4(NM_004485.3) - SHH092711 from Creative biogene
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Human GNG4 siRNA - orb262360 from Biorbyt
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GNG4 shRNA Plasmid (Human) - CHH1858 from Cohesion Biosciences
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GNG4 miRNA 3'UTR clone - MiUTR1H-04115 from Creative biogene
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