| Gene Symbol | Amacr |
|---|---|
| Entrez Gene | 25284 |
| Alt Symbol | Da1-8, Marc1 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | alpha-methylacyl-CoA racemase |
| Other Description | 2-arylpropionyl-CoA epimerase|2-methylacyl-CoA racemase |
| Swissprots | P70473 O09176 |
| Accessions | EDL82982 P70473 AY325250 AAP92651 BC078885 AAH78885 BC091163 AAH91163 BC127505 AAI27506 FM061736 U89905 AAB72145 Y08172 CAA69358 NM_012816 NP_036948 |
| Function | Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers. Has a role in drug metabolism as well as probably in lipid metabolism. The 2- arylpropionic acid (2-APA's) derivatives, including ibuprofen, are the most widely used anti-inflammatory analgesic cyclooxygenase inhibitors. The (-)-R-enantiomer, which is inactive in terms of cyclooxygenase inhibition, is epimerized in vivo via this enzyme to the cyclooxygenase-inhibiting (+)-S-enantiomer. |
| Subcellular Location | Peroxisome. Mitochondrion. |
| Top Pathways | Primary bile acid biosynthesis, Peroxisome |