Gene Symbol | SSC5D |
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Entrez Gene | 284297 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | scavenger receptor cysteine rich family, 5 domains |
Other Description | scavenger receptor cysteine rich domain containing (5 domains)|scavenger receptor cysteine-rich glycoprotein|soluble scavenger protein with 5 SRCR domains|soluble scavenger receptor cysteine-rich domain-containing protein SSC5D|soluble scavenger with 5 domains |
Swissprots | K7EP70 B5MDQ5 C7S7U0 A1L4H1 C7S7T9 |
Accessions | A1L4H1 AF086519 AK092577 BAC03917 BC130538 AAI30539 BC130540 AAI30541 DA008417 EU699476 ACJ02751 EU699477 ACJ02752 XM_011526758 XP_011525060 XM_011526759 XP_011525061 NM_182571 NM_001144950 NP_001138422 NM_001195267 NP_001182196 |
Function | Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted {ECO:0000250}. Cytoplasm {ECO:0000250}. |
Tissue Specificity | Highly expressed in monocytes/macrophages and T-lymphocytes. Highly expressed in placenta and spleen, and also detected at lower levels in colon, and more weakly in lung, heart and kidney. {ECO:0000269|PubMed:19535143}. |
SSc5D CRISPR/Cas9 KO Plasmid (h) - sc-418823 from Santa Cruz Biotechnology
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SSc5D HDR Plasmid (h) - sc-418823-HDR from Santa Cruz Biotechnology
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SSc5D Double Nickase Plasmid (h) - sc-418823-NIC from Santa Cruz Biotechnology
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SSc5D Double Nickase Plasmid (h2) - sc-418823-NIC-2 from Santa Cruz Biotechnology
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SSc5D CRISPR Activation Plasmid (h) - sc-418823-ACT from Santa Cruz Biotechnology
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SSc5D CRISPR Activation Plasmid (h2) - sc-418823-ACT-2 from Santa Cruz Biotechnology
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SSc5D Lentiviral Activation Particles (h) - sc-418823-LAC from Santa Cruz Biotechnology
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SSc5D Lentiviral Activation Particles (h2) - sc-418823-LAC-2 from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN20619 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20619 from Sigma-Aldrich
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SSC5D siRNA (Human) - CRJ6991 from Cohesion Biosciences
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SSC5D - MBS8223285 from MyBioSource
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shRNA set against Human SSC5D (NM_001144950.1) - SHH418396 from Creative biogene
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Human SSC5D siRNA - orb277492 from Biorbyt
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SSC5D shRNA Plasmid (Human) - CHJ6991 from Cohesion Biosciences
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SSC5D miRNA 3'UTR clone - MiUTR3H-15348 from Creative biogene
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