Gene Symbol | Cyp2e1 |
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Entrez Gene | 13106 |
Alt Symbol | Cyp2e |
Species | Mouse |
Gene Type | protein-coding |
Description | cytochrome P450, family 2, subfamily e, polypeptide 1 |
Other Description | 4-nitrophenol 2-hydroxylase|CYPIIE1|cytochrome P450 2E1|cytochrome P450, 2e1, ethanol inducible|cytochrome P450-ALC|cytochrome P450-J |
Swissprots | Q9Z198 Q05421 |
Accessions | EDL17941 EDL17942 EDL17943 EDL17944 EDL17945 EDL17946 Q05421 BC013451 AAH13451 BC042693 DQ838976 ABH07947 DQ838977 ABH07948 L11650 AAA39879 M27582 M54877 AAA37275 X01026 CAA25510 X62595 CAA44481 NM_021282 NP_067257 |
Function | Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
Tissue Specificity | Highest level in the liver and to a lesser extent in the kidney, with a higher level in the male kidney than in the female. |
Top Pathways | Steroid hormone biosynthesis, Chemical carcinogenesis, Non-alcoholic fatty liver disease (NAFLD), Arachidonic acid metabolism, Linoleic acid metabolism |
CYP2E1 CRISPR/Cas9 KO Plasmid (m) - sc-419917 from Santa Cruz Biotechnology
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CYP2E1 HDR Plasmid (m) - sc-419917-HDR from Santa Cruz Biotechnology
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CYP2E1 Double Nickase Plasmid (m) - sc-419917-NIC from Santa Cruz Biotechnology
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CYP2E1 Double Nickase Plasmid (m2) - sc-419917-NIC-2 from Santa Cruz Biotechnology
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CYP2E1 CRISPR Activation Plasmid (m) - sc-419917-ACT from Santa Cruz Biotechnology
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CYP2E1 CRISPR Activation Plasmid (m2) - sc-419917-ACT-2 from Santa Cruz Biotechnology
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CYP2E1 Lentiviral Activation Particles (m) - sc-419917-LAC from Santa Cruz Biotechnology
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CYP2E1 Lentiviral Activation Particles (m2) - sc-419917-LAC-2 from Santa Cruz Biotechnology
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CYP2E1 siRNA (m) - sc-142699 from Santa Cruz Biotechnology
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CYP2E1 shRNA Plasmid (m) - sc-142699-SH from Santa Cruz Biotechnology
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CYP2E1 shRNA (m) Lentiviral Particles - sc-142699-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN29537 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND29537 from Sigma-Aldrich
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CYP2E1 siRNA (Mouse) - CRM0946 from Cohesion Biosciences
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CYP2E1 - MBS8222176 from MyBioSource
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shRNA set against Mouse CYP2E1 (NM_021282.2) - SHH273301 from Creative biogene
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shRNA set against Mouse Cyp2e1(NM_021282.2) - SHG217069 from Creative biogene
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Mouse CYP2E1 siRNA - orb280422 from Biorbyt
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CYP2E1 shRNA Plasmid (Mouse) - CHM0946 from Cohesion Biosciences
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CYP2E1 miRNA 3'UTR clone - MiUTR1M-03537 from Creative biogene
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