| Gene Symbol | BIRC5 |
|---|---|
| Entrez Gene | 332 |
| Alt Symbol | API4, EPR-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | baculoviral IAP repeat containing 5 |
| Other Description | apoptosis inhibitor 4|apoptosis inhibitor survivin|baculoviral IAP repeat-containing protein 5|survivin variant 3 alpha |
| Swissprots | Q75SP2 Q2I3N8 Q9P2W8 Q4VGX0 B2R4R1 O15392 A2SUH6 Q53F61 Q5MGC6 Q6FHL2 |
| Accessions | AAC51660 AAV40840 CCA94579 EAW89511 EAW89512 EAW89513 EAW89514 O15392 AB028869 BAA93676 AB154416 BAD11155 AF077350 AAD34226 AI800528 AK223428 BAD97148 AK301793 BAH13555 AK311917 BAG34858 AL519719 AL547142 AM393128 CAL38006 AY830084 AAW22624 AY927772 AAY15202 BC000784 BC008718 AAH08718 BC034148 AAH34148 BC065497 AAH65497 BE537971 BG178974 BG759111 BI254058 BI520186 BM476145 BQ687404 CB112371 CR541740 CAG46540 DQ227257 ABB76601 DQ310375 ABC42341 DQ310376 ABC42342 DQ310377 ABC42343 DQ310378 ABC42344 DQ310379 ABC42345 DQ508245 ABF60110 DQ508246 ABF60111 DQ508247 ABF60112 DQ508248 ABF60113 DQ508249 ABF60114 HM625836 ADM26643 XR_243654 XR_934452 NM_001012270 NP_001012270 NM_001012271 NP_001012271 NM_001168 NP_001159 |
| Function | Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked red |
| Subcellular Location | Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1- mediated nuclear export. |
| Tissue Specificity | Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines. {ECO:0000269|PubMed:10626797, ECO:0000269|PubMed:14741722, ECO:0000269|PubMed:16329164}. |
| Top Pathways | Colorectal cancer, Hippo signaling pathway |