| Gene Symbol |
CALCOCO1
|
| Entrez Gene |
57658
|
| Alt Symbol |
Cocoa, PP13275, calphoglin
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcium binding and coiled-coil domain 1
|
| Other Description |
calcium-binding and coiled-coil domain-containing protein 1|coiled-coil coactivator protein|coiled-coil leucine zipper coactivator 1|inorganic pyrophosphatase activator|sarcoma antigen NY-SAR-3
|
| Swissprots |
Q9H090 Q71RC3 Q9P1Z2 Q96JU3 Q86WF8 Q6FI59 B3KVA8
|
| Accessions |
EAW96727 EAW96728 EAW96729 EAW96730 EAW96731 EAW96732 EAW96733 Q9P1Z2 AB040969 BAA96060 AF370415 AAQ15251 AK027881 BAB55428 AK092788 BAG52609 AK122773 BAG53720 AK222646 AK294424 BAG57671 AK296497 BAG59131 AK309199 AK315578 AL136895 CAB66829 AM393253 CAL38131 AY211909 AAO65163 AY358397 AAQ88763 AY563137 AAT68474 BC003177 AAH03177 BX538208 CAD98068 CD723746 CR533567 CAG38598 DB060684 XM_011538601 XP_011536903 XM_011538602 XP_011536904 XM_011538603 XP_011536905 XM_011538604 XP_011536906 NM_001143682 NP_001137154 NM_020898 NP_065949 NR_026554
|
| Function |
Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1- mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. {ECO:0000250}.
|
![Western Blot: CoCoA Overexpression Lysate (Adult Normal) [NBL1-08645] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CoCoA.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1263_CoCoA%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08645-img0002.jpg)