AKR1A1

Gene Symbol	AKR1A1
Entrez Gene	10327
Alt Symbol	ALDR1, ALR, ARM, DD3, HEL-S-6
Species	Human
Gene Type	protein-coding
Description	aldo-keto reductase family 1, member A1 (aldehyde reductase)
Other Description	HEL-S-165mP|alcohol dehydrogenase|alcohol dehydrogenase [NADP(+)]|aldehyde reductase|aldo-keto reductase family 1 member A1|dihydrodiol dehydrogenase 3|epididymis secretory protein Li 6|epididymis secretory sperm binding protein Li 165mP
Swissprots	Q6IAZ4 P14550 D3DQ04 A8KAL8
Accessions	AAB92369 AAF01260 EAX06970 EAX06971 EAX06972 EAX06973 EAX06974 P14550 AK293083 BAF85772 AK307068 AK307237 AK307288 AK311175 AU142853 BC000670 AAH00670 BC005394 AAH05394 BC033287 BI549149 BT007003 AAP35649 BU631634 CR457010 CAG33291 CX788871 DA550374 DA871469 DQ890682 ABM81608 DQ893770 ABM84696 DQ893865 ABM84791 EU668319 ACF94472 EU794588 ACJ13642 J04794 AAA51711 XM_011540491 XP_011538793 XM_011540492 XP_011538794 XR_946517 NM_001202414 NP_001189343 NM_006066 NP_006057 NM_153326 NP_697021 NM_001202413 NP_001189342
Function	Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). {ECO:0000269|PubMed:10510318, ECO:0000269|PubMed:11306097, ECO:0000269|PubMed:18276838}.
Tissue Specificity	Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung. {ECO:0000269|PubMed:10510318, ECO:0000269|PubMed:11306097}.
Top Pathways	Glycolysis / Gluconeogenesis, Pentose and glucuronate interconversions, Glycerolipid metabolism, Degradation of aromatic compounds

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human AKR1A1 full length protein - ab95472 from Abcam Category Protein Prices $188.00, $692.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human AKR1A1 full length protein - ab117169 from Abcam Category Protein Prices $188.00 Sizes 5 µg Source E. coli Species Human

Human AKR1A1 peptide - ab23210 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

AKR1A1 Antibody Blocking Peptide - LS-E23525 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AKR1A1 Antibody Blocking Peptide - LS-E23524 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AKR1A1 Antibody Blocking Peptide - LS-E25395 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AKR1A1 Antibody Blocking Peptide - LS-E7054 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AKR1A1 Recombinant Protein - H00010327-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human AKR1A1 Protein - NBP1-30170 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

AKR1A1 Peptide - P1225 from Novus Biologicals Category Peptide Species Human

AKR1A1-Antibody-C-term-Blocking-Peptide - BP2734b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AKR1A1 Protein (OPPA01978) - OPPA01978 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human AK1A1 protein - orb138146 from Biorbyt Category Protein Prices $298.00, $612.00 Sizes 20 μg, 100 μg Source E. coli Species Human

Human AKR1A1 protein - orb90019 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli Species Human

AKR1A1 Blocking Peptide - abx063664 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Pig

AKR1A1 Peptide - AC21-0223-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

AKR1A1 / ALDR1 (1-325) - AR09316PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Human

AKR1A1 / ALDR1 (1-325) - AR09316PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Human

AKR1A1 / ALDR1 - H00010327-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

AKR1A1 / ALDR1 - H00010327-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Aldo-Keto Reductase Family 1 Member A1, Human Recombinant - 228-12483-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Aldo-Keto Reductase Family 1 Member A1 - 228-12483-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Aldo-Keto Reductase Family 1 Member A1 - 228-12483-3 from RayBiotech Category Protein Prices $2,400.00 Sizes 3 µg Source Escherichia Coli. Species Human

Alcohol dehydrogenase, 1-325aa, Human, E.coli - 01-1746 from ARP American Research Products Category Protein Prices $159.00, $339.00, $749.00 Sizes 20 µg, 100 µg, 500 µg Species Human

Aldehyde Reductase Peptide - 45-237P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

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