| Gene Symbol |
CHORDC1
|
| Entrez Gene |
26973
|
| Alt Symbol |
CHP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cysteine and histidine-rich domain (CHORD) containing 1
|
| Other Description |
CHORD-containing protein 1|CHP-1|chord domain-containing protein 1|cysteine and histidine-rich domain (CHORD)-containing 1|cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1|cysteine and histidine-rich domain-containing protein 1|protein morgana
|
| Swissprots |
B2R6P8 Q6IN49 Q9H3D6 Q9UHD1 Q8WVL9
|
| Accessions |
EAW66867 EAW66868 EAW66869 EAW66870 EAW66871 Q9UHD1 AF123249 AAG43237 AF192466 AAF18437 AF217505 AAF67616 AK022848 AK094608 AK225365 AK225565 AK226099 AK290231 BAF82920 AK312663 BAG35545 BC002339 BC017789 AAH17789 BC072461 AAH72461 CB852298 CF146721 CK300454 DA417105 HQ447579 ADQ32065 XM_011542747 XP_011541049 XM_011542748 XP_011541050 XM_011542749 XP_011541051 NM_001144073 NP_001137545 NM_012124 NP_036256
|
| Function |
Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis. {ECO:0000269|PubMed:20230755}.
|
| Tissue Specificity |
Underexpressed in many breast and lung cancers. {ECO:0000269|PubMed:20230755}.
|