HSP90AB1

Gene Symbol HSP90AB1
Entrez Gene 3326
Alt Symbol D6S182, HSP84, HSP90B, HSPC2, HSPCB
Species Human
Gene Type protein-coding
Description heat shock protein 90kDa alpha (cytosolic), class B member 1
Other Description HSP90-beta|heat shock 84 kDa|heat shock 90kD protein 1, beta|heat shock protein HSP 90-beta
Swissprots Q5T9W7 P08238 Q9NQW0 Q9NTK6 B2R5P0
Accessions AAA36026 ABC40731 BAA22050 EAX04257 EAX04258 EAX04259 EAX04260 P08238 AF275719 AAF82792 AK025370 BAB15121 AK130494 AK290734 BAF83423 AK294643 BAG57821 AK297367 BAG59814 AK312255 BAG35187 AL136543 CAB66478 AY359878 AAQ63401 BC004928 AAH04928 BC007327 AAH07327 BC009206 AAH09206 BC012807 AAH12807 BC014485 AAH14485 BC016753 AAH16753 BC068474 AAH68474 BE539681 BG482327 BI252490 BQ028821 BX420114 BX649079 CD653541 CX761569 D28342 BAA05708 DC340766 DC341882 DC350708 DC365600 DQ893024 ABM83950 DQ896268 ABM87267 M16660 AAA36025 NM_001271969 NP_001258898 NM_001271970 NP_001258899 NM_001271971 NP_001258900 NM_001271972 NP_001258901 NM_007355 NP_031381 NR_073528
Function Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:19696785}.
Subcellular Location Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Top Pathways Progesterone-mediated oocyte maturation, Prostate cancer, NOD-like receptor signaling pathway, Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway

HSP90β (D3F2) Rabbit mAb - 7411 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3F2
Western blot analysis of extracts from various cell lines using HSP90β (D3F2) Rabbit mAb.

HSP90β Antibody - 5087 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using HSP90β Antibody.

HSP 90β (D-19) - sc-1057 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HSP 90β (D-19): sc-1057. Western blot analysis of HSP 90β expression in HeLa whole cell lysate.

p-HSP 90 (Ser 254) - sc-101701 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of phosphorylated HSP 90 expression in HT29 whole cell lysate (A,B). Blots were probed with p-HSP 90 (Ser 254): sc-101701 preincubated with its cognate phosphorylated peptide (A) and p-HSP 90 (Ser 254): sc-101701 (B).

Anti-Hsp90 beta (phospho S226) antibody - ab63562 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Hsp90 beta (phospho S226) antibody (ab63562) at 1/500 dilutionLane 1 : extracts from A549 cells, treated with serum (20%, 15mins)Lane 2 : extracts from A549 cells, treated with serum (20%, 15mins) with immunizing phosphopeptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-Hsp90 beta (phospho S254) antibody - ab51136 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab51136 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab51136, 1µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM

Anti-Hsp90 beta (phospho S254) antibody - ab192173 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Hsp90 beta (phospho S254) antibody (ab192173) at 1/500 dilutionLane 1 : TNF-a treated HeLa whole cell lysates treated with the antigen-specific peptideLane 2 : TNF-a treated HeLa whole cell lysatesLysates/proteins at 12.5 µg per lane.

Anti-Hsp90 beta antibody - ab80159 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab80159 at 1/100 dilution staining Hsp90 in mouse back skin tissue section by Immunohistochemistry (Bouin's fixative fixed paraffin-embedded tissue section). Antigen retrieval was done by microwave in citrate buffer. A Fluorophore-conjugated goat anti-rabbit secondary was used at 1/10 dilution.

Anti-Hsp90 beta antibody - ab51145 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Hsp90 beta antibody (ab51145) at 1/500 dilutionLane 1 : extracts from Hela cells treated with TNF-aLane 2 : extracts from Hela cells treated with TNF-a with immunizing peptideLysates/proteins at 0.02 µg/ml per lane.

Anti-Hsp90 beta antibody - ab196939 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Hsp90 beta antibody (ab196939) at 1/500 dilutionLane 1 : Extracts from HeLa cells treated with TNF alpha (20ng/ml, 30min)Lane 2 : Extracts from HeLa cells treated with TNF alpha (20ng/ml, 30min) with synthesized peptide

Anti-Hsp90 beta antibody - ab154511 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Hsp90 beta antibody (ab154511) at 1/2000 dilution + HeLa S3 whole cell lysate at 30 µg

Anti-Hsp90 beta antibody - ab63367 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Hsp90 beta antibody (ab63367) at 1/500 dilutionLane 1 : extracts from 293 cellsLane 2 : extracts from 293 cells with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-Hsp90 beta antibody - ab126810 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Hsp90 beta antibody (ab126810) at 1/1000 dilutionLane 1 : Human recombinant Hsp90 alpha Lane 2 : Human recombinant Hsp90 beta Lysates/proteins at 0.02 µg per lane.

Anti-Hsp90 beta antibody [5G4] - ab119833 from Abcam

Prices $398.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5G4
All lanes : Anti-Hsp90 beta antibody [5G4] (ab119833) at 1/500 dilutionLane 1 : Jurkat cell lysateLane 2 : A431 cell lysateLane 3 : Hela cell lysateLane 4 : A549 cell lysateLane 5 : HEK293 cell lysateLane 6 : K562 cell lysateLane 7 : NIH 3T3 cell lysateLane 8 : PC12 cell lysateLane 9 : Cos7 cell lysate

Anti-Hsp90 beta antibody [E296] - ab32568 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone E296
All lanes : Anti-Hsp90 beta antibody [E296] (ab32568) at 1/100000 dilution (purified)Lane 1 : Mouse brain tissue lysateLane 2 : Mouse heart tissue lysateLane 3 : Rat brain tissue lysateLane 4 : Rat heart tissue lysateLysates/proteins at 20 µg per lane.SecondaryHRP goat anti-rabbit (H+L) at 1/1000 dilution

Anti-Hsp90 beta antibody [EPR16621] - ab203085 from Abcam

Prices $99.00
Sizes 10 µl
Host Rabbit
Clonality Monoclonal
Clone EPR16621
Immunofluorescence analysis of 4% paraformaldehyde fixed HeLa cells (Human epithelial cells from cervix adenocarcinoma) labeling Hsp90 beta with ab203085 at a 1/250 dilution showing cytoplasmic staining. Permeabilisation using 0.1% tritonX-100.Secondary ab: Anti-Rabbit Alexa Fluor® 488 (ab150077) at 1/200 dilution. Counter stain is labeling tubulin (red) with ab7291 at 1/500 dilution with secondary antibody Anti-Mouse AlexaFluor® 594 (ab150120) at 1/400 dilution. DAPI stains the nucleus in blue. -ve control 1 is ab178854 at 1/250 dilution, Anti-Mouse AlexaFluor® 594 (ab150120) at 1/400 dilution. -ve control 2 is ab7291 at 1/500 dilution, Anti-Rabbit Alexa Fluor® 488 (ab150077) at 1/200 dilution.

Anti-HSP90AB1 / HSP90 Alpha B1 Antibody (phospho-Ser254) - LS-C192179 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (IHC) analysis of p-HSP90 beta (S254) pAb in paraffin-embedded human breast cancer tissue.

Anti-HSP90AB1 / HSP90 Alpha B1 Antibody (aa149-357, clone 1D9) IHC-plus™ - LS-B10734 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 1D9
Anti-HSP90AB1 / HSP90 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10734 dilution 1:50.

Anti-HSP90AB1 / HSP90 Alpha B1 Antibody (aa149-357, clone 5G4) IHC-plus™ - LS-B10733 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 5G4
Anti-HSP90AB1 / HSP90 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10733 dilution 1:50.

Anti-HSP90AB1 / HSP90 Alpha B1 Antibody - LS-C335129 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded mouse kidney using HSP90AB1 antibody at dilution of 1:500 (200x lens).

Anti-HSP90AB1 / HSP90 Alpha B1 Antibody (DY650) - LS-C180774 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HSP90AB1 / HSP90 Alpha B1 Antibody - LS-C136847 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HSP90AB1 / HSP90 Alpha B1 Antibody (DY488) - LS-C180775 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HSP90AB1 / HSP90 Alpha B1 Antibody (N-Terminus, clone E296) - LS-C49480 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone E296
IHC of paraffin-embedded urinary bladder carcinoma using anti-Hsp90 beta (N-term) antibody.

Anti-HSP90AB1 / HSP90 Alpha B1 Antibody (DY550) - LS-C180776 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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