| Gene Symbol |
HSP90AB1
|
| Entrez Gene |
3326
|
| Alt Symbol |
D6S182, HSP84, HSP90B, HSPC2, HSPCB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
heat shock protein 90kDa alpha (cytosolic), class B member 1
|
| Other Description |
HSP90-beta|heat shock 84 kDa|heat shock 90kD protein 1, beta|heat shock protein HSP 90-beta
|
| Swissprots |
Q5T9W7 P08238 Q9NQW0 Q9NTK6 B2R5P0
|
| Accessions |
AAA36026 ABC40731 BAA22050 EAX04257 EAX04258 EAX04259 EAX04260 P08238 AF275719 AAF82792 AK025370 BAB15121 AK130494 AK290734 BAF83423 AK294643 BAG57821 AK297367 BAG59814 AK312255 BAG35187 AL136543 CAB66478 AY359878 AAQ63401 BC004928 AAH04928 BC007327 AAH07327 BC009206 AAH09206 BC012807 AAH12807 BC014485 AAH14485 BC016753 AAH16753 BC068474 AAH68474 BE539681 BG482327 BI252490 BQ028821 BX420114 BX649079 CD653541 CX761569 D28342 BAA05708 DC340766 DC341882 DC350708 DC365600 DQ893024 ABM83950 DQ896268 ABM87267 M16660 AAA36025 NM_001271969 NP_001258898 NM_001271970 NP_001258899 NM_001271971 NP_001258900 NM_001271972 NP_001258901 NM_007355 NP_031381 NR_073528
|
| Function |
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:19696785}.
|
| Subcellular Location |
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
|
| Top Pathways |
Progesterone-mediated oocyte maturation, Prostate cancer, NOD-like receptor signaling pathway, Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway
|
![Western Blot: Hsp90B Overexpression Lysate (Adult Normal) [NBL1-11745] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Hsp90B.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9984_Hsp90B%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11745-img0002.jpg)