| Gene Symbol |
TGFA
|
| Entrez Gene |
7039
|
| Alt Symbol |
TFGA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transforming growth factor, alpha
|
| Other Description |
TGF-alpha|protransforming growth factor alpha
|
| Swissprots |
A8K286 Q9UKM2 Q15577 Q9UEI3 Q9UKM1 P01135 Q9UKM3 Q53SK7 Q9BS56
|
| Accessions |
AAA52530 AAA61158 AAA79958 AAD12238 AAD12239 AAF06728 AAF06729 AAF06730 AAF13491 AAP97822 AAY14705 AAY14793 EAW99810 EAW99811 EAW99812 EAW99813 EAW99814 P01135 AF149096 AAF05089 AF149097 AAF05090 AF149098 AAF05091 AK290151 BAF82840 AK309066 AK309220 AK312899 AY548763 AAS83396 BC005308 AAH05308 BI760767 BM453873 BT006833 AAP35479 CD369689 CN274505 DA216480 DA229819 DA373586 DA462271 K03222 AAA61159 M31172 AAA61157 X70340 CAA49806 XM_005264522 XP_005264579 XM_011533076 XP_011531378 NM_001099691 NP_001093161 NM_001308159 NP_001295088 NM_003236 NP_003227 NM_001308158 NP_001295087
|
| Function |
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
|
| Subcellular Location |
Transforming growth factor alpha: Secreted, extracellular space.
|
| Tissue Specificity |
Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. {ECO:0000269|PubMed:10523832}.
|
| Top Pathways |
Non-small cell lung cancer, Renal cell carcinoma, Pancreatic cancer, Glioma, Prostate cancer
|
![Western Blot: TGF alpha Overexpression Lysate (Adult Normal) [NBL1-16851] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TGF alpha.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9358_TGF%2520alpha%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16851-img0002.jpg)