KMT2A

Gene Symbol	KMT2A
Entrez Gene	4297
Alt Symbol	ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1, MLL1A, TET1-MLL, TRX1, WDSTS
Species	Human
Gene Type	protein-coding
Description	lysine (K)-specific methyltransferase 2A
Other Description	CDK6/MLL fusion protein|CXXC-type zinc finger protein 7|MLL-AF4 der(11) fusion protein|MLL/GAS7 fusion protein|MLL/GMPS fusion protein|histone-lysine N-methyltransferase 2A|lysine N-methyltransferase 2A|mixed lineage leukemia 1|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)|trithorax-like protein|zinc finger protein HRX
Swissprots	E9PQG7 Q03164 Q13744 Q16364 Q13743 Q14845 Q6UBD1 Q9UD94 Q59FF2 Q9UMA3 Q9HBJ3
Accessions	AAA18644 AAC95283 AAC95284 AAQ63624 AAQ91347 CAA58584 CAA93625 CAB56460 CCO13771 EAW67380 EAW67381 EAW67382 EAW67383 EAW67384 Q03164 AB209508 BAD92745 AF024540 AAC51814 AF232000 AAG26334 AF232001 AAG26335 AF272370 AAG31978 AF272371 AAG31979 AF272372 AF272378 AAG31983 AF272379 AF272380 AAG31984 AF272381 AAG31985 AF272382 AAG31986 AF487906 AAM14566 AF512944 AAM82546 AK021845 AK295635 BAG58509 AK303179 BAG64274 AY187942 AAO38742 AY187943 AAO38743 AY187944 AAO38744 AY187945 AAO38745 BC015388 BC039603 BC065385 BC090876 D14540 BAA03407 DQ224341 ABB29493 FM165198 CAQ60122 JF938536 L01986 AAA92511 L04284 AAA58669 L04731 S66432 AAB28545 S78570 AAB34770 S78571 AAB34771 S82034 XM_006718839 XP_006718902 XM_011542829 XP_011541131 XM_011542830 XP_011541132 XM_011542831 XP_011541133 XM_011542832 XP_011541134 XM_011542833 XP_011541135 NM_001197104 NP_001184033 NM_005933 NP_005924 NM_024891
Function	Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permi
Subcellular Location	MLL cleavage product C180: Nucleus. Note=Localizes to a diffuse nuclear pattern when not associated with MLL cleavage product N320.
Tissue Specificity	Heart, lung, brain and T- and B-lymphocytes.
Top Pathways	Lysine degradation, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MLL + ASH2L + RBBP5 + WDR5 full length protein - ab135021 from Abcam Category Protein Prices $820.00 Sizes 50 µg Source Baculovirus infected sf9 cells Species Human

Human KMT2A / MLL peptide - ab27875 from Abcam Category Peptide

KMT2A / MLL Antibody Blocking Peptide - LS-E860 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KMT2A/MLL Peptide - P0240 from Novus Biologicals Category Peptide Species Human

HRX-Antibody-C-term-Blocking-Peptide - BP1123b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GAGA-POZ - PRPS-442 from NeoScientific Category Protein Prices $65.00, $169.00, $2,340.00 Sizes 10 µg, 50 µg, 1 mg Source Escherichia Coli.

Recombinant MLL / HRX - SET protein - 31419 from ActiveMotif Category Protein Prices $395.00, $3,200.00 Sizes 50 µg, 1 mg Source E. coli Species Human

Recombinant Mouse Ddr1, His-tagged - Ddr1-1150M from Creative Biomart Category Protein Source Mouse

GAGA-POZ domain(1-130aa) - PRM-223 from Reagent Proteins Category Protein Prices $406.00, $700.00 Sizes 100.00 µg, 500 µg Source E.coli Species Human

Thioredoxin-1 - TGR-288 from Reagent Proteins Category Protein Prices $406.00, $700.00 Sizes 100.00 µg, 500 µg Source E.coli Species Human

GAGA POZ - PAT-80090-1 from Nordic BioSite Category Protein Species Human

GAGA POZ - PAT-80090-2 from Nordic BioSite Category Protein Species Human

Recombinant MLL1 Complex - 31423 from ActiveMotif Prices $415.00, $3,500.00 Sizes 20 µg, 1 mg Source E. coli Species Human

Recombinant Human KMT2A Protein, His-tagged - KMT2A-127H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human KMT2A Complex, His-tagged - KMT2A-128H from Creative Biomart Category Protein Source E.coli Species Human

MLL-HRX-Antibody-Center-Blocking-peptide - BP1123c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MLL-HRX-Antibody-N-term-Blocking-peptide - BP2518a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MLL1-Antibody-C-term-Blocking-Peptide - BP6182a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MLL Peptide, Human - M34GP09563H from Creative Peptides Category Peptide Source Synthetic. Species Human

KMT2A/MLL Recombinant Protein Antigen - NBP2-55237PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MLL1, Recombinant Protein - MBS515546 from MyBioSource Category Protein Prices $315.00, $425.00 Sizes 5 µg, 10 µg Source Sf9 insect cells using baculovirus Species Human

KMT2A fusion protein - Ag26759 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T

MLL fusion protein - Ag27159 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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