| Gene Symbol | KHDRBS2 |
|---|---|
| Entrez Gene | 202559 |
| Alt Symbol | SLM-1, SLM1, bA535F17.1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | KH domain containing, RNA binding, signal transduction associated 2 |
| Other Description | KH domain-containing, RNA-binding, signal transduction-associated protein 2|Sam68-like mammalian protein 1|hSLM-1 |
| Swissprots | Q8N4I4 Q8TCZ4 A8K7M8 Q5VWX1 |
| Accessions | CCQ43867 EAW88489 EAW88490 EAW88491 Q5VWX1 AK095983 BAG53185 AK292043 BAF84732 AY077838 AAL77219 BC034043 AAH34043 BI597067 D60325 HQ447866 ADQ32350 LN608117 XM_006715354 XP_006715417 XM_011535515 XP_011533817 XM_011535516 XP_011533818 XM_011535517 XP_011533819 XM_011535518 XP_011533820 XM_011535519 XP_011533821 XM_011535520 XP_011533822 XR_427965 XR_942323 NM_152688 NP_689901 |
| Function | RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. |
| Tissue Specificity | Highly expressed in brain, lung, kidney and small intestine. Weakly expressed in placenta, liver, spleen, thymus, ovary and colon. {ECO:0000269|PubMed:12549823}. |