Gene Symbol | PHF10 |
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Entrez Gene | 55274 |
Alt Symbol | BAF45A, XAP135 |
Species | Human |
Gene Type | protein-coding |
Description | PHD finger protein 10 |
Other Description | BRG1-associated factor 45a|BRG1-associated factor, 45-KD, A|PHD zinc finger protein XAP135 |
Swissprots | Q8WUB8 Q2YDA3 Q9NV26 Q53HG8 Q9BXD2 |
Accessions | AAK27451 EAW47442 EAW47443 EAW47444 Q8WUB8 AJ420510 AK001837 BAA91934 AK222612 BAD96332 AK296349 BAG59032 AL133094 BC020954 AAH20954 BC110323 AAI10324 CR457273 CAG33554 DB460742 DQ891432 ABM82358 DQ894607 ABM85533 KC839988 AGQ46690 KC839989 AGQ46691 NM_018288 NP_060758 NM_133325 NP_579866 |
Function | Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulatin |
Subcellular Location | Nucleus {ECO:0000250}. |
PHF10 (N-16) - sc-107936 from Santa Cruz Biotechnology
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Anti-PHF10 antibody - ab154637 from Abcam
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Anti-PHF10 antibody - ab80939 from Abcam
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Anti-PHF10 antibody - ab68114 from Abcam
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Anti-PHF10 antibody - ab118479 from Abcam
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Anti-PHF10 Antibody (aa290-339) - LS-C81304 from LifeSpan Bioscience
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Anti-PHF10 Antibody (aa153-401) - LS-C178637 from LifeSpan Bioscience
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PHF10 Antibody - NBP2-19795 from Novus Biologicals
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PHF10 Antibody - NBP1-52879 from Novus Biologicals
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PHF10 Antibody - NBP2-33759 from Novus Biologicals
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PHF10 Antibody - H00055274-B01P from Novus Biologicals
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PHF10 Antibody - H00055274-D01 from Novus Biologicals
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Anti-PHF10 antibody produced in mouse - SAB1400609 from Sigma-Aldrich
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Anti-PHF10 antibody produced in rabbit - SAB2701275 from Sigma-Aldrich
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Anti-PHF10 antibody produced in rabbit - SAB2101784 from Sigma-Aldrich
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Anti-PHF10 antibody produced in rabbit - HPA055649 from Sigma-Aldrich
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PHF10 antibody - middle region (ARP48833_P050) - ARP48833_P050 from Aviva Systems Biology
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PHF10 antibody - orb78010 from Biorbyt
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PHF10 antibody - 70R-2002 from Fitzgerald
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PHF10 Antibody - abx036576 from Abbexa
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PHF10 antibody - H00055274-B01P from Acris Antibodies
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PHF10 antibody - H00055274-D01 from Acris Antibodies
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PHF10 Antibody - 26-352 from ProSci
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PHF10 antibody - 17145-1-AP from Proteintech Group
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PHF10 Antibody - 39614 from Signalway Antibody
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