| Gene Symbol |
PHF10
|
| Entrez Gene |
55274
|
| Alt Symbol |
BAF45A, XAP135
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PHD finger protein 10
|
| Other Description |
BRG1-associated factor 45a|BRG1-associated factor, 45-KD, A|PHD zinc finger protein XAP135
|
| Swissprots |
Q8WUB8 Q2YDA3 Q9NV26 Q53HG8 Q9BXD2
|
| Accessions |
AAK27451 EAW47442 EAW47443 EAW47444 Q8WUB8 AJ420510 AK001837 BAA91934 AK222612 BAD96332 AK296349 BAG59032 AL133094 BC020954 AAH20954 BC110323 AAI10324 CR457273 CAG33554 DB460742 DQ891432 ABM82358 DQ894607 ABM85533 KC839988 AGQ46690 KC839989 AGQ46691 NM_018288 NP_060758 NM_133325 NP_579866
|
| Function |
Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulatin
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|