RAD51C

Gene Symbol RAD51C
Entrez Gene 5889
Alt Symbol BROVCA3, FANCO, R51H3, RAD51L2
Species Human
Gene Type protein-coding
Description RAD51 paralog C
Other Description DNA repair protein RAD51 homolog 3|RAD51-like protein 2|yeast RAD51 homolog 3
Swissprots Q3B783 O43503 O43502
Accessions AAT38108 EAW94430 EAW94431 EAW94432 EAW94433 EAW94434 O43502 AA304618 AF029669 AAC39604 AF029670 AAC39605 AI424321 AI914449 AK129738 AK290487 BAF83176 AK303363 BAG64422 BC000667 BC064578 BC073161 BC093930 AAH93930 BC101485 AAI01486 BC107753 AAI07754 BC143259 BM987503 BT007339 AAP36003 CB243543 XM_006722001 XP_006722064 XM_006722002 XP_006722065 XM_006722004 XP_006722067 XM_006722005 XP_006722068 XM_011525092 XP_011523394 XM_011525093 XP_011523395 XM_011525094 XP_011523396 XR_934513 XR_934514 NM_002876 NP_002867 NM_058216 NP_478123 NR_103872 NR_103873
Function Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response
Subcellular Location Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=DNA damage induces an increase in nuclear levels. Accumulates in DNA damage induced nuclear foci or RAD51C foci which is formed during the S or G2 phase of cell cycle. Accumulation at DNA lesions requires the presence of NBN/NBS1, ATM and RPA.
Tissue Specificity Expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen and prostate.
Top Pathways Homologous recombination, Fanconi anemia pathway

Rad51C (2H11) - sc-56214 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rad51C (2H11): sc-56214. Western blot analysis of Rad51C expression in HEK293 (A), ES-2 (B) and PCEP-4 (C) whole cell lysates.

Rad51C (F-11) - sc-390697 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rad51C (F-11): sc-390697. Western blot analysis of Rad51C expression in HEK293 (A) and ES-2 (B) whole cell lysates.

Rad51C (H-157) - sc-367079 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Rad51C (N-19) - sc-27328 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Rad51C antibody - ab55728 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Rad51C antibody - ab72063 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Rad51C antibody (ab72063) at 1/500 dilutionLane 1 : Extracts from COS-7 cellsLane 2 : Extracts from COS-7 cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-Rad51C antibody - ab3669 from Abcam

Prices $378.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-Rad51C antibody - ab95069 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Rad51C antibody (ab95069) at 0.1 µg/mlLane 1 : Whole cell lysate from HeLa cells at 50 µgLane 2 : Whole cell lysate from HeLa cells at 15 µgLane 3 : Whole cell lysate from HeLa cells at 5 µgLane 4 : Whole cell lysate from 293T cells at 50 µgdeveloped using the ECL technique

Anti-Rad51C antibody - ab124121 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Rad51C antibody (ab124121) at 1/100 dilution + HepG2 cell line lysates at 35 µg

Anti-RAD51C Antibody (Glu185) - LS-C176982 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Rad51C (E185) pAb in extracts from COS-7 cells.

Anti-RAD51C Antibody (aa2-14) - LS-C34651 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
RAD51C antibody staining (2 ug/ml) of HeLa lysate (RIPA buffer, 30g total protein per lane). Primary incubated for 12 hour. Detected by Western blot of chemiluminescence.

Anti-RAD51C Antibody (aa1-135, Azide-free) - LS-C328455 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-RAD51C Antibody (aa168-198) - LS-C324506 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RAD51C Antibody - LS-C346156 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-RAD51C Antibody (aa161-210) - LS-C199514 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from COS7 cells, using RAD51L2 Antibody. The lane on the right was incubated with synthetic peptide.

Anti-RAD51C Antibody (aa169-198) - LS-C162411 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
RAD51C Antibody western blot of HepG2 cell line lysates (35 ug/lane). The RAD51C antibody detected the RAD51C protein (arrow).

Anti-RAD51C Antibody (aa326-376) - LS-C289369 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human RAD51C by Western Blot. Samples: Whole cell lysate from HeLa (5, 15 and 50 ug) and 293T (T; 50 ug) cells. Antibody: Affinity purified rabbit anti-RAD51C antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-RAD51C Antibody (clone 3F3-5C6) - LS-C198054 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F3-5C6
Immunofluorescence of monoclonal antibody to RAD51C on HeLa cell. [antibody concentration 10 ug/ml]

Anti-RAD51C Antibody (aa70-84) - LS-C9869 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RAD51C Antibody (clone 2H11/6, Biotin) - LS-C140851 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2H11/6

Anti-RAD51C Antibody (clone 2H11/6, DY488) - LS-C140853 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2H11/6

Anti-RAD51C Antibody (clone 2H11/6, DY650) - LS-C140852 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2H11/6

Anti-RAD51C Antibody (clone 2H11/6, HRP) - LS-C140854 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2H11/6

Anti-RAD51C Antibody (clone 2H11/6, DY550) - LS-C140855 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2H11/6

Anti-RAD51C Antibody (aa169-198, AP) - LS-C267763 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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