| Gene Symbol |
GRM7
|
| Entrez Gene |
2917
|
| Alt Symbol |
GLUR7, GPRC1G, MGLU7, MGLUR7, PPP1R87
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glutamate receptor, metabotropic 7
|
| Other Description |
metabotropic glutamate receptor 7|protein phosphatase 1, regulatory subunit 87
|
| Swissprots |
Q8NFS3 Q8NFS4 Q8NFS2 Q14831
|
| Accessions |
CCQ42994 EAW63933 EAW63934 EAW63935 Q14831 AB209214 BAD92451 AI701722 AK097817 AK123326 AK312488 BAG35390 AW511101 BC136458 AAI36459 BC136459 AAI36460 X94552 CAA64245 XM_011533648 XP_011531950 XR_940422 NM_000844 NP_000835 NM_181874 NP_870989 NM_181875
|
| Function |
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:9473604}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4. {ECO:0000269|PubMed:12052533, ECO:0000269|PubMed:8840028}.
|
| Top Pathways |
Glutamatergic synapse, Neuroactive ligand-receptor interaction
|
![Western Blot: mGluR7 Overexpression Lysate (Adult Normal) [NBL1-11351] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for mGluR7.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3003_mGluR7%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11351-img0002.jpg)