| Gene Symbol |
GPD1L
|
| Entrez Gene |
23171
|
| Alt Symbol |
GPD1-L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glycerol-3-phosphate dehydrogenase 1-like
|
| Other Description |
glycerol-3-phosphate dehydrogenase 1-like protein
|
| Swissprots |
Q14702 Q8N335 A8K9U3 Q9BRM5
|
| Accessions |
EAW64421 EAW64422 Q8N335 AI080105 AK074221 AK125404 BAG54194 AK292808 BAF85497 BC006168 AAH06168 BC028726 AAH28726 BX283865 D42047 BAA07648 DA318838 XM_005264983 XP_005265040 XM_006713068 XP_006713131 NM_015141 NP_055956
|
| Function |
Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. {ECO:0000269|PubMed:19666841, ECO:0000269|PubMed:19745168}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:17967977}. Note=Localized to the region of the plasma membrane.
|
| Tissue Specificity |
Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs. {ECO:0000269|PubMed:17967977}.
|
| Top Pathways |
Glycerophospholipid metabolism
|