| Gene Symbol |
ATP6V0A4
|
| Entrez Gene |
50617
|
| Alt Symbol |
A4, ATP6N1B, ATP6N2, RDRTA2, RTA1C, RTADR, STV1, VPH1, VPP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATPase, H+ transporting, lysosomal V0 subunit a4
|
| Other Description |
ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1B|ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kD)|H(+)-transporting two-sector ATPase, noncatalytic accessory protein 1B|V-ATPase 116 kDa|V-type proton ATPase 116 kDa subunit a|V-type proton ATPase 116 kDa subunit a isoform 4|vacuolar proton pump 116 kDa accessory subunit|vacuolar proton pump, subunit 2|vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform
|
| Swissprots |
Q32M47 A8KA80 A4D1R4 Q9HBG4
|
| Accessions |
CBX47558 CBX47559 CBX47560 EAL24043 EAW83892 EAW83893 EAW83894 EAW83895 EAW83896 EAW83897 Q9HBG4 AF245517 AAG11415 AK055789 BAB71014 AK292945 BAF85634 BC109304 AAI09305 BC109305 AAI09306 DA857655 DB230144 XM_005250393 XP_005250450 XM_005250394 XP_005250451 NM_020632 NP_065683 NM_130840 NP_570855 NM_130841 NP_570856
|
| Function |
Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney. {ECO:0000250}.
|
| Subcellular Location |
Apical cell membrane; Multi-pass membrane protein. Note=Present at high density almost exclusively on the apical surface of alpha-intercalated cells in the cortical collecting ducts of the distal nephron.
|
| Tissue Specificity |
Expressed in adult and fetal kidney. Found in the inner ear. {ECO:0000269|PubMed:12414817}.
|
| Top Pathways |
Collecting duct acid secretion, Tuberculosis, Synaptic vesicle cycle, Rheumatoid arthritis, Phagosome
|