ATP6V0A4
| Gene Symbol | ATP6V0A4 |
|---|---|
| Entrez Gene | 50617 |
| Alt Symbol | A4, ATP6N1B, ATP6N2, RDRTA2, RTA1C, RTADR, STV1, VPH1, VPP2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATPase, H+ transporting, lysosomal V0 subunit a4 |
| Other Description | ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1B|ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kD)|H(+)-transporting two-sector ATPase, noncatalytic accessory protein 1B|V-ATPase 116 kDa|V-type proton ATPase 116 kDa subunit a|V-type proton ATPase 116 kDa subunit a isoform 4|vacuolar proton pump 116 kDa accessory subunit|vacuolar proton pump, subunit 2|vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform |
| Swissprots | Q32M47 A8KA80 A4D1R4 Q9HBG4 |
| Accessions | CBX47558 CBX47559 CBX47560 EAL24043 EAW83892 EAW83893 EAW83894 EAW83895 EAW83896 EAW83897 Q9HBG4 AF245517 AAG11415 AK055789 BAB71014 AK292945 BAF85634 BC109304 AAI09305 BC109305 AAI09306 DA857655 DB230144 XM_005250393 XP_005250450 XM_005250394 XP_005250451 NM_020632 NP_065683 NM_130840 NP_570855 NM_130841 NP_570856 |
| Function | Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney. {ECO:0000250}. |
| Subcellular Location | Apical cell membrane; Multi-pass membrane protein. Note=Present at high density almost exclusively on the apical surface of alpha-intercalated cells in the cortical collecting ducts of the distal nephron. |
| Tissue Specificity | Expressed in adult and fetal kidney. Found in the inner ear. {ECO:0000269|PubMed:12414817}. |
| Top Pathways | Collecting duct acid secretion, Tuberculosis, Synaptic vesicle cycle, Rheumatoid arthritis, Phagosome |
V-ATPase A4 CRISPR/Cas9 KO Plasmid (h) - sc-406133 from Santa Cruz Biotechnology
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V-ATPase A4 HDR Plasmid (h) - sc-406133-HDR from Santa Cruz Biotechnology
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V-ATPase A4 Double Nickase Plasmid (h) - sc-406133-NIC from Santa Cruz Biotechnology
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V-ATPase A4 Double Nickase Plasmid (h2) - sc-406133-NIC-2 from Santa Cruz Biotechnology
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V-ATPase A4 CRISPR Activation Plasmid (h) - sc-406133-ACT from Santa Cruz Biotechnology
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V-ATPase A4 CRISPR Activation Plasmid (h2) - sc-406133-ACT-2 from Santa Cruz Biotechnology
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V-ATPase A4 Lentiviral Activation Particles (h) - sc-406133-LAC from Santa Cruz Biotechnology
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V-ATPase A4 Lentiviral Activation Particles (h2) - sc-406133-LAC-2 from Santa Cruz Biotechnology
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V-ATPase A4 siRNA (h) - sc-63203 from Santa Cruz Biotechnology
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V-ATPase A4 shRNA Plasmid (h) - sc-63203-SH from Santa Cruz Biotechnology
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V-ATPase A4 shRNA (h) Lentiviral Particles - sc-63203-V from Santa Cruz Biotechnology
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ATP6V0A4 RNAi - H00050617-R03 from Novus Biologicals
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ATP6V0A4 RNAi - H00050617-R01 from Novus Biologicals
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ATP6V0A4 RNAi - H00050617-R02 from Novus Biologicals
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MISSION® esiRNA - EHU132531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3719 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3719 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02021 from Sigma-Aldrich
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ATP6V0A4 siRNA (Human) - CRH9389 from Cohesion Biosciences
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ATP6V0A4 - MBS8214915 from MyBioSource
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shRNA set against Human ATP6V0A4 (NM_020632.2) - SHH243002 from Creative biogene
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Human ATP6V0A4 siRNA - orb269891 from Biorbyt
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ATP6V0A4 shRNA Plasmid (Human) - CHH9389 from Cohesion Biosciences
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ATP6V0A4 miRNA 3'UTR clone - MiUTR1H-00708 from Creative biogene
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ATP6V0A4 miRNA 3'UTR clone - MiUTR3H-07505 from Creative biogene
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