| Gene Symbol | DCK |
|---|---|
| Entrez Gene | 1633 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | deoxycytidine kinase |
| Other Description | deoxynucleoside kinase |
| Swissprots | Q5TZY7 B2R8V6 P27707 Q6FI11 |
| Accessions | AAG36929 CCA94561 CCD32997 EAX05637 P27707 AK303292 BAG64367 AK313523 BAG36303 BC103764 AAI03765 BC114617 AAI14618 BI601939 BT019941 AAV38744 BT019942 AAV38745 CD014016 CR536527 CAG38764 CR541876 CAG46674 JF806429 AED02503 M60527 AAA35752 NM_000788 NP_000779 |
| Function | Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. {ECO:0000269|PubMed:18377927, ECO:0000269|PubMed:20614893}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:9342341}. |
| Top Pathways | Purine metabolism, Pyrimidine metabolism |