CYP4F2

Gene Symbol CYP4F2
Entrez Gene 8529
Alt Symbol CPF2
Species Human
Gene Type protein-coding
Description cytochrome P450, family 4, subfamily F, polypeptide 2
Other Description 20-HETE synthase|20-hydroxyeicosatetraenoic acid synthase|CYPIVF2|arachidonic acid omega-hydroxylase|cytochrome P450 4F2|cytochrome P450, subfamily IVF, polypeptide 2|cytochrome P450-LTB-omega|leukotriene-B(4) 20-monooxygenase 1|leukotriene-B(4) omega-hydroxylase 1|phylloquinone omega-hydroxylase CYP4F2
Swissprots A0A024R7K3 Q9UIU8 Q9NNZ0 Q6NWT6 A8K425 P78329 Q16677 B4DV75 Q6NWT4
Accessions AAC27730 AAF86378 AAL67578 BAA75823 EAW84508 EAW84509 EAW84510 P78329 AK290790 BAF83479 AK296200 BAG58928 AK300961 BAG62587 AK313705 BC067437 AAH67437 BC067438 BC067439 AAH67439 BC067440 AAH67440 D26480 BAA05490 DC362034 U02388 AAC50052 NM_001082 NP_001073
Function Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531). Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), possibly influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070). Also acts as a leukotriene-B(4) omega-hydroxylase by mediating conversion of leukotriene-B(4) (LTB4) to its omega-hydroxylated metabolite 20-hydroxyleukotriene- B(4) (20-OH LTB4) (PubMed:8026587, PubMed:9799565). {ECO:0000269|PubMed:10660572, ECO:0000269|PubMed:17341693, ECO:0000269|PubMed:18574070, ECO:0000269|PubMed:19297519, ECO:0000269|PubMed:2413
Subcellular Location Microsome membrane {ECO:0000269|PubMed:19297519, ECO:0000269|PubMed:24138531, ECO:0000269|PubMed:8026587}; Peripheral membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20861217}; Peripheral membrane protein {ECO:0000305}.
Tissue Specificity Liver. Also present in kidney: specifically expressed in the S2 and S3 segments of proximal tubules in cortex and outer medulla (PubMed:10660572). {ECO:0000269|PubMed:10492403, ECO:0000269|PubMed:10660572}.
Top Pathways Arachidonic acid metabolism

cytochrome P450, family 4, subfamily F, polypeptide 2, ELISA Kit - MBS9328848 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Cytochrome P450 4F2 (CYP4F2) - SEL399Hu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.55ng/mL.
Range 1.56-100ng/mL The standard curve concentrations used for the ELISA’s were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.13ng/mL, 1.56ng/mL

ELISA Kit for Cytochrome P450 4F2 (CYP4F2) - SEL399Hu from Cloud-clone

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.55ng/mL.
Range 1.563-100ng/mL The standard curve concentrations used for the ELISA's were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL

Human Cytochrome P450 4F2 (CYP4F2) ELISA Kit - EKU09309 from Biomatik

Category ELISA Kit
Prices $809.00, $3,557.00, $6,468.00
Sizes 96 t, 5x96t, 10x96t
Sensitivity 0.59 ng/mL
Range 1.56-100 ng/mL

CYP4F2 ELISA Kit (Human) (OKEH01660) - OKEH01660 from Aviva Systems Biology

Category ELISA Kit
Prices $420.00
Sizes 96 wells
Sensitivity < 0.33 ng/mL
Range 0.312 - 20 ng/mL

Human CYP4F2 ELISA Kit - E011090 from Biobool

Category ELISA Kit
Sensitivity 0.55ng/mL.

CYP4F2 ELISA Kit (Human) (OKCD02045) - OKCD02045 from Aviva Systems Biology

Category ELISA Kit
Prices $585.00
Sizes 96 wells
Sensitivity < 0.59 ng/mL
Range 1.56 - 100 ng/mL

Human Leukotriene-B(4) omega-hydroxylase 1 ELISA Kit - EK4532 from Signalway Antibody

Category ELISA Kit
Prices $599.00
Sizes 1x96t
Range 78-5000 pg/ml

Cytochrome P450 4F2, ELISA Kit - MBS2031971 from MyBioSource

Category ELISA Kit
Prices $410.00, $610.00, $830.00, $3,420.00, $6,200.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.55ng/mL.
Range 1.56-100ng/mL. The standard curve concentrations used for the ELISA's were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.12ng/mL, 1.56ng/mL.

Leukotriene-B (4) omega-hydroxylase 1, ELISA Kit - MBS9428358 from MyBioSource

Category ELISA Kit
Prices $555.00
Sizes 96 tests
Range 0.312-20 ng/mL

Leukotriene-B(4) omega-hydroxylase 1, ELISA Kit - MBS2887815 from MyBioSource

Category ELISA Kit
Prices $380.00, $500.00, $2,170.00, $3,840.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Range 0.312-20 ng/mL

Human CYP4F2 ELISA Kit (Sandwich ELISA) - LS-F39102 from LifeSpan Bioscience

Category ELISA Kit
Sensitivity 0.55
Range 1.56-100 ng/ml
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