| Gene Symbol |
CYP4F2
|
| Entrez Gene |
8529
|
| Alt Symbol |
CPF2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 4, subfamily F, polypeptide 2
|
| Other Description |
20-HETE synthase|20-hydroxyeicosatetraenoic acid synthase|CYPIVF2|arachidonic acid omega-hydroxylase|cytochrome P450 4F2|cytochrome P450, subfamily IVF, polypeptide 2|cytochrome P450-LTB-omega|leukotriene-B(4) 20-monooxygenase 1|leukotriene-B(4) omega-hydroxylase 1|phylloquinone omega-hydroxylase CYP4F2
|
| Swissprots |
A0A024R7K3 Q9UIU8 Q9NNZ0 Q6NWT6 A8K425 P78329 Q16677 B4DV75 Q6NWT4
|
| Accessions |
AAC27730 AAF86378 AAL67578 BAA75823 EAW84508 EAW84509 EAW84510 P78329 AK290790 BAF83479 AK296200 BAG58928 AK300961 BAG62587 AK313705 BC067437 AAH67437 BC067438 BC067439 AAH67439 BC067440 AAH67440 D26480 BAA05490 DC362034 U02388 AAC50052 NM_001082 NP_001073
|
| Function |
Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531). Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), possibly influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070). Also acts as a leukotriene-B(4) omega-hydroxylase by mediating conversion of leukotriene-B(4) (LTB4) to its omega-hydroxylated metabolite 20-hydroxyleukotriene- B(4) (20-OH LTB4) (PubMed:8026587, PubMed:9799565). {ECO:0000269|PubMed:10660572, ECO:0000269|PubMed:17341693, ECO:0000269|PubMed:18574070, ECO:0000269|PubMed:19297519, ECO:0000269|PubMed:2413
|
| Subcellular Location |
Microsome membrane {ECO:0000269|PubMed:19297519, ECO:0000269|PubMed:24138531, ECO:0000269|PubMed:8026587}; Peripheral membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20861217}; Peripheral membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Liver. Also present in kidney: specifically expressed in the S2 and S3 segments of proximal tubules in cortex and outer medulla (PubMed:10660572). {ECO:0000269|PubMed:10492403, ECO:0000269|PubMed:10660572}.
|
| Top Pathways |
Arachidonic acid metabolism
|