CYP4F2

Gene Symbol CYP4F2
Entrez Gene 8529
Alt Symbol CPF2
Species Human
Gene Type protein-coding
Description cytochrome P450, family 4, subfamily F, polypeptide 2
Other Description 20-HETE synthase|20-hydroxyeicosatetraenoic acid synthase|CYPIVF2|arachidonic acid omega-hydroxylase|cytochrome P450 4F2|cytochrome P450, subfamily IVF, polypeptide 2|cytochrome P450-LTB-omega|leukotriene-B(4) 20-monooxygenase 1|leukotriene-B(4) omega-hydroxylase 1|phylloquinone omega-hydroxylase CYP4F2
Swissprots A0A024R7K3 Q9UIU8 Q9NNZ0 Q6NWT6 A8K425 P78329 Q16677 B4DV75 Q6NWT4
Accessions AAC27730 AAF86378 AAL67578 BAA75823 EAW84508 EAW84509 EAW84510 P78329 AK290790 BAF83479 AK296200 BAG58928 AK300961 BAG62587 AK313705 BC067437 AAH67437 BC067438 BC067439 AAH67439 BC067440 AAH67440 D26480 BAA05490 DC362034 U02388 AAC50052 NM_001082 NP_001073
Function Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531). Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), possibly influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070). Also acts as a leukotriene-B(4) omega-hydroxylase by mediating conversion of leukotriene-B(4) (LTB4) to its omega-hydroxylated metabolite 20-hydroxyleukotriene- B(4) (20-OH LTB4) (PubMed:8026587, PubMed:9799565). {ECO:0000269|PubMed:10660572, ECO:0000269|PubMed:17341693, ECO:0000269|PubMed:18574070, ECO:0000269|PubMed:19297519, ECO:0000269|PubMed:2413
Subcellular Location Microsome membrane {ECO:0000269|PubMed:19297519, ECO:0000269|PubMed:24138531, ECO:0000269|PubMed:8026587}; Peripheral membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20861217}; Peripheral membrane protein {ECO:0000305}.
Tissue Specificity Liver. Also present in kidney: specifically expressed in the S2 and S3 segments of proximal tubules in cortex and outer medulla (PubMed:10660572). {ECO:0000269|PubMed:10492403, ECO:0000269|PubMed:10660572}.
Top Pathways Arachidonic acid metabolism

CYP4F2 Antibody Blocking Peptide - LS-E23242 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Cytochrome P450 4F2 Blocking Peptide - abx063487 from Abbexa

Category Peptide
Species Human, Mouse, Rat

Recombinant Human CYP4F2 - CYP4F2-555H from Creative Biomart

Category Protein
Source baculovirus infected insect cells
Species Human

Cytochrome P450 4F2 Blocking Peptide - CBP2293 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human, Mouse, Rat

CYP4F2 Peptide - BS5690P from Bioworld Technology

Category Peptide
Prices $158.00
Sizes 100 µl

CYP4F2 (M66) Peptide - BS9135P from Bioworld Technology

Category Peptide
Prices $158.00
Sizes 100 µl

Recombinant Human Leukotriene-B(4) omega-hydroxylase 1(CYP4F2) - CSB-YP006451HU CSB-EP006451HU CSB-BP006451HU CSB-MP006451HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

CYP4F2 Recombinant Protein Antigen - NBP1-86461PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

CYP4F2-Antibody-N-term-Blocking-Peptide - BP9059a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CYP4F2 Peptide, Human - M34GP03980H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Leukotriene-B (4) omega-hydroxylase 1 (CYP4F2), Recombinant Protein - MBS948523 from MyBioSource

Category Protein
Prices $1,765.00, $1,920.00, $2,085.00, $2,195.00, $2,395.00, $2,415.00, $2,750.00, $2,995.00, $3,475.00, $4,340.00
Sizes 50 µg (Baculovirus), 500 µg (E-Coli), 500 µg (Yeast), 100 µg (Baculovirus), 1 mg (E-Coli), 50 µg (Mammalian-Cell), 1 mg (Yeast), 100 µg (Mammalian-Cell), 500 µg (Baculovirus), 1 mg (Baculovirus)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

CYP4F2 fusion protein - Ag26523 from Proteintech Group

Category Protein
Source E. coli -derived, PGEX-4T
Species Human
Search more