CYP4F2

Gene Symbol CYP4F2
Entrez Gene 8529
Alt Symbol CPF2
Species Human
Gene Type protein-coding
Description cytochrome P450, family 4, subfamily F, polypeptide 2
Other Description 20-HETE synthase|20-hydroxyeicosatetraenoic acid synthase|CYPIVF2|arachidonic acid omega-hydroxylase|cytochrome P450 4F2|cytochrome P450, subfamily IVF, polypeptide 2|cytochrome P450-LTB-omega|leukotriene-B(4) 20-monooxygenase 1|leukotriene-B(4) omega-hydroxylase 1|phylloquinone omega-hydroxylase CYP4F2
Swissprots A0A024R7K3 Q9UIU8 Q9NNZ0 Q6NWT6 A8K425 P78329 Q16677 B4DV75 Q6NWT4
Accessions AAC27730 AAF86378 AAL67578 BAA75823 EAW84508 EAW84509 EAW84510 P78329 AK290790 BAF83479 AK296200 BAG58928 AK300961 BAG62587 AK313705 BC067437 AAH67437 BC067438 BC067439 AAH67439 BC067440 AAH67440 D26480 BAA05490 DC362034 U02388 AAC50052 NM_001082 NP_001073
Function Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531). Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), possibly influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070). Also acts as a leukotriene-B(4) omega-hydroxylase by mediating conversion of leukotriene-B(4) (LTB4) to its omega-hydroxylated metabolite 20-hydroxyleukotriene- B(4) (20-OH LTB4) (PubMed:8026587, PubMed:9799565). {ECO:0000269|PubMed:10660572, ECO:0000269|PubMed:17341693, ECO:0000269|PubMed:18574070, ECO:0000269|PubMed:19297519, ECO:0000269|PubMed:2413
Subcellular Location Microsome membrane {ECO:0000269|PubMed:19297519, ECO:0000269|PubMed:24138531, ECO:0000269|PubMed:8026587}; Peripheral membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20861217}; Peripheral membrane protein {ECO:0000305}.
Tissue Specificity Liver. Also present in kidney: specifically expressed in the S2 and S3 segments of proximal tubules in cortex and outer medulla (PubMed:10660572). {ECO:0000269|PubMed:10492403, ECO:0000269|PubMed:10660572}.
Top Pathways Arachidonic acid metabolism

CYP4F2 CRISPR/Cas9 KO Plasmid (h) - sc-409719 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP4F2 HDR Plasmid (h) - sc-409719-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP4F2 Double Nickase Plasmid (h) - sc-409719-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP4F2 Double Nickase Plasmid (h2) - sc-409719-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP4F2 CRISPR Activation Plasmid (h) - sc-409719-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP4F2 CRISPR Activation Plasmid (h2) - sc-409719-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP4F2 Lentiviral Activation Particles (h) - sc-409719-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP4F2 Lentiviral Activation Particles (h2) - sc-409719-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP4F2 siRNA (h) - sc-60488 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CYP4F2 shRNA Plasmid (h) - sc-60488-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CYP4F2 shRNA (h) Lentiviral Particles - sc-60488-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CYP4F2 RNAi - H00008529-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU127161 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU112821 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1898 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1898 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06768 from Sigma-Aldrich

Category miRNA

CYP4F2 siRNA (Human) - CRH5600 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CYP4F2 - MBS8214649 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CYP4F2 (NM_001082.3) - SHH273681 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CYP4F2(NM_001082.3) - SHG217561 from Creative biogene

Category siRNA
Species Reactivities Human

Human CYP4F2 siRNA - orb266102 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CYP4F2 shRNA Plasmid (Human) - CHH5600 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CYP4F2 miRNA 3'UTR clone - MiUTR1H-02639 from Creative biogene

Species Reactivities Human
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