| Gene Symbol | Insig1 |
|---|---|
| Entrez Gene | 64194 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | insulin induced gene 1 |
| Other Description | INSIG-1|growth response protein (CL-6)|immediate-early protein CL-6|insulin-induced gene 1 protein|insulin-induced growth response protein CL-6 |
| Swissprots | Q08755 |
| Accessions | EDL86413 Q08755 BC078827 AAH78827 L13619 AAA40938 NM_022392 NP_071787 |
| Function | Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth (By similarity). {ECO:0000250}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Highly expressed in liver and kidney. |
insulin induced gene 1, ELISA Kit - MBS9330408 from MyBioSource
|
||||||
Rat Insig1 ELISA Kit - E086782 from Biobool
|