| Gene Symbol |
Insig1
|
| Entrez Gene |
64194
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
insulin induced gene 1
|
| Other Description |
INSIG-1|growth response protein (CL-6)|immediate-early protein CL-6|insulin-induced gene 1 protein|insulin-induced growth response protein CL-6
|
| Swissprots |
Q08755
|
| Accessions |
EDL86413 Q08755 BC078827 AAH78827 L13619 AAA40938 NM_022392 NP_071787
|
| Function |
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in liver and kidney.
|