| Gene Symbol | Insig1 |
|---|---|
| Entrez Gene | 64194 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | insulin induced gene 1 |
| Other Description | INSIG-1|growth response protein (CL-6)|immediate-early protein CL-6|insulin-induced gene 1 protein|insulin-induced growth response protein CL-6 |
| Swissprots | Q08755 |
| Accessions | EDL86413 Q08755 BC078827 AAH78827 L13619 AAA40938 NM_022392 NP_071787 |
| Function | Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth (By similarity). {ECO:0000250}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Highly expressed in liver and kidney. |
CompoZr® Knockout ZFN Kit - CKOZFN55503 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND55503 from Sigma-Aldrich
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INSIG1 siRNA (Rat) - CRR1834 from Cohesion Biosciences
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INSIG1 - MBS8229420 from MyBioSource
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shRNA set against Rat INSIG1 (NM_022392.1) - SHH319829 from Creative biogene
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shRNA set against Rat Insig1(NM_022392.1) - SHL178986 from Creative biogene
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INSIG1 shRNA Plasmid (Rat) - CHR1834 from Cohesion Biosciences
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INSIG1 miRNA 3'UTR clone - MiUTR1R-02677 from Creative biogene
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