| Gene Symbol |
SRD5A3
|
| Entrez Gene |
79644
|
| Alt Symbol |
CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
steroid 5 alpha-reductase 3
|
| Other Description |
3-oxo-5-alpha-steroid 4-dehydrogenase 3|S5AR 3|SR type 3|polyprenol reductase|probable polyprenol reductase
|
| Swissprots |
Q4W5Q6 Q9H8P0
|
| Accessions |
AAY40904 EAX05465 Q9H8P0 AK023414 BAB14568 BC002480 AAH02480 CR457312 CAG33593 CX763068 DB532427 HQ447832 ADQ32316 XM_005265766 XP_005265823 XM_005265767 XP_005265824 NM_024592 NP_078868
|
| Function |
Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT). {ECO:0000269|PubMed:17986282, ECO:0000269|PubMed:20637498}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000305|PubMed:20637498}; Multi-pass membrane protein {ECO:0000305|PubMed:20637498}.
|
| Tissue Specificity |
Overexpressed in hormone-refractory prostate cancers (HRPC). Almost no or little expression in normal adult organs. {ECO:0000269|PubMed:17986282}.
|
| Top Pathways |
Steroid hormone biosynthesis
|