NGLY1

Gene Symbol NGLY1
Entrez Gene 55768
Alt Symbol CDG1V, PNG1, PNGase
Species Human
Gene Type protein-coding
Description N-glycanase 1
Other Description hPNGase|peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase|peptide:N-glycanase
Swissprots Q6PJD8 Q96IV0 Q9BVR8 Q59FB1 Q9NR70 B4DJE9
Accessions EAW64363 EAW64364 EAW64365 EAW64366 Q96IV0 AB114414 AB114415 AB209549 BAD92786 AF250924 AAF74720 AK001867 BAA91950 AK022471 AK296047 BAG58811 AK310473 AL832748 BC000963 AAH00963 BC007226 AAH07226 BC017220 AAH17220 BQ017148 DC329733 DQ893509 ABM84435 DQ896501 ABM87500 XM_005265316 XP_005265373 XM_005265317 XP_005265374 XM_011533944 XP_011532246 XM_011533945 XP_011532247 XR_940470 XR_940471 NM_001145293 NP_001138765 NM_001145294 NP_001138766 NM_001145295 NP_001138767 NM_018297 NP_060767 NM_025105
Function Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. {ECO:0000269|PubMed:14749736, ECO:0000269|PubMed:15358861}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15358861}.
Top Pathways Protein processing in endoplasmic reticulum

PNGase (C-19) - sc-103126 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PNGase (N-15) - sc-103128 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-NGLY1 antibody - ab197107 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-NGLY1 antibody (ab197107) at 1/500 dilution + HeLa cell lysate

Anti-NGLY1 antibody - ab73984 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NGLY1 Antibody (C-Terminus) - LS-C144866 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NGLY1 Antibody (Internal) - LS-C345852 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of NGLY1 Antibody with human 786-0 Whole Cell lysate.

NGLY1 Antibody - NBP1-18966 from Novus Biologicals

Prices $329.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

NGLY1 Antibody - NBP1-83792 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: NGLY1 Antibody [NBP1-83792] - Staining of human testis shows strong cytoplasmic positivity in cells in seminiferous ducts and Leydig cells.

Anti-NGLY1 antibody produced in rabbit - HPA036825 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-NGLY1: <B>Cat. No. HPA036825</B>: Immunohistochemical staining of human stomach shows strong cytoplasmic positivity, with a granular pattern in glandular cells.

NGLY1 Antibody - middle region (ARP75684_P050) - ARP75684_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NGLY1 Antibody - middle region (OAAB03745) - OAAB03745 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

NGLY1 antibody - AP55141SU-N from Acris Antibodies

Prices $460.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

NGLY1 antibody - 17307-1-AP from Proteintech Group

Host Rabbit
Clonality Polyclonal

Anti-NGLY1 (aa 100-200) polyclonal antibody - DPABH-17521 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-NGLY1 monoclonal antibody - DCABH-201044 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal

NGLY1, Polyclonal Antibody - MBS623625 from MyBioSource

Prices $550.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Peptide-N(4)-(N-acetyl-beta-glucosaminyl)... - pab0422 from Covalab

Host Rabbit
Clonality Polyclonal

NGLY1 Antibody - abx122116 from Abbexa

Host Rabbit
Clonality Polyclonal

NGLY1 antibody (FITC) - orb222404 from Biorbyt

Prices $315.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

Anti-NGLY1 Antibody A06013 - A06013 from Boster Bio

Prices $299.00
Sizes 1
Host Rabbit
Clonality Polyclonal

NGLY1 Antibody - A305-547A from Bethyl Labs

Prices $99.00, $229.00, $339.00
Sizes 20 µl (2 blots), 100 µl (10 blots), 100 µl (1 mg/ml)
Host Rabbit
Clonality Polyclonal

Anti-NGLY1 polyclonal antibody - CABT-B8983 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

NGLY1 Antibody - middle region : Biotin (ARP75684_P050-Biotin) - ARP75684_P050-Biotin from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal

NGLY1 Antibody - middle region : FITC (ARP75684_P050-FITC) - ARP75684_P050-FITC from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal

NGLY1 Antibody - middle region : HRP (ARP75684_P050-HRP) - ARP75684_P050-HRP from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal
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