NGLY1

Gene Symbol	NGLY1
Entrez Gene	55768
Alt Symbol	CDG1V, PNG1, PNGase
Species	Human
Gene Type	protein-coding
Description	N-glycanase 1
Other Description	hPNGase|peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase|peptide:N-glycanase
Swissprots	Q6PJD8 Q96IV0 Q9BVR8 Q59FB1 Q9NR70 B4DJE9
Accessions	EAW64363 EAW64364 EAW64365 EAW64366 Q96IV0 AB114414 AB114415 AB209549 BAD92786 AF250924 AAF74720 AK001867 BAA91950 AK022471 AK296047 BAG58811 AK310473 AL832748 BC000963 AAH00963 BC007226 AAH07226 BC017220 AAH17220 BQ017148 DC329733 DQ893509 ABM84435 DQ896501 ABM87500 XM_005265316 XP_005265373 XM_005265317 XP_005265374 XM_011533944 XP_011532246 XM_011533945 XP_011532247 XR_940470 XR_940471 NM_001145293 NP_001138765 NM_001145294 NP_001138766 NM_001145295 NP_001138767 NM_018297 NP_060767 NM_025105
Function	Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. {ECO:0000269|PubMed:14749736, ECO:0000269|PubMed:15358861}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15358861}.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-NGLY1-cDNA-Clone - DC02106 from Abgent, a WuXi AppTec company Prices $882.90 Sizes 10 µg Species Human Accession BC007226

NGLY1 - MBS1272599 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC007226

Human NGLY1 cDNA clone(NM_001145293.1) - CDFH012524 from Creative Biomart Species Human Accession NM_001145293.1

Human NGLY1 cDNA clone(NM_001145294.1) - CDFH012525 from Creative Biomart Species Human Accession NM_001145294.1

Human NGLY1 cDNA clone(NM_001145295.1) - CDFH012526 from Creative Biomart Species Human Accession NM_001145295.1

Human NGLY1 ORF Clone(NM_001145293.1) - CDCR352584 from Creative Biomart Species Human Accession NM_001145293.1

Human NGLY1 ORF Clone(NM_001145294.1) - CDCR352585 from Creative Biomart Species Human Accession NM_001145294.1

Human NGLY1 ORF Clone(NM_001145294.1) - CDCR352586 from Creative Biomart Species Human Accession NM_001145294.1

Human NGLY1 ORF Clone(NM_001145295.1) - CDCR352587 from Creative Biomart Species Human Accession NM_001145295.1

Human NGLY1 ORF Clone(NM_001145295.1) - CDCR352588 from Creative Biomart Species Human Accession NM_001145295.1

Human NGLY1 ORF Clone(NM_001145293.1) - CDCR352589 from Creative Biomart Species Human Accession NM_001145293.1

Human NGLY1 Gene ORF cDNA clone in cloning vector - HG15563-G from Sino Biological Species Human

Human NGLY1 Gene ORF cDNA clone expression plasmid, N-His tag - HG15563-NH from Sino Biological Species Human

Human NGLY1 Gene ORF cDNA clone expression plasmid, C-His tag - HG15563-CH from Sino Biological Species Human

Human NGLY1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG15563-CY from Sino Biological Species Human

Human NGLY1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG15563-NF from Sino Biological Species Human

Human NGLY1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG15563-CF from Sino Biological Species Human

Human NGLY1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG15563-NM from Sino Biological Species Human

Human NGLY1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG15563-CM from Sino Biological Species Human

Human NGLY1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG15563-ANG from Sino Biological Species Human

Human NGLY1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG15563-ACG from Sino Biological Species Human

Human NGLY1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG15563-NY from Sino Biological Species Human

Human NGLY1 Gene ORF cDNA clone expression plasmid - HG15563-UT from Sino Biological Species Human

Human NGLY1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG15563-ACR from Sino Biological Species Human

Mouse NGLY1 ORF clone (NM_001145293.1) - CDCL138227 from Creative biogene Species Human

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