NGLY1

Gene Symbol NGLY1
Entrez Gene 55768
Alt Symbol CDG1V, PNG1, PNGase
Species Human
Gene Type protein-coding
Description N-glycanase 1
Other Description hPNGase|peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase|peptide:N-glycanase
Swissprots Q6PJD8 Q96IV0 Q9BVR8 Q59FB1 Q9NR70 B4DJE9
Accessions EAW64363 EAW64364 EAW64365 EAW64366 Q96IV0 AB114414 AB114415 AB209549 BAD92786 AF250924 AAF74720 AK001867 BAA91950 AK022471 AK296047 BAG58811 AK310473 AL832748 BC000963 AAH00963 BC007226 AAH07226 BC017220 AAH17220 BQ017148 DC329733 DQ893509 ABM84435 DQ896501 ABM87500 XM_005265316 XP_005265373 XM_005265317 XP_005265374 XM_011533944 XP_011532246 XM_011533945 XP_011532247 XR_940470 XR_940471 NM_001145293 NP_001138765 NM_001145294 NP_001138766 NM_001145295 NP_001138767 NM_018297 NP_060767 NM_025105
Function Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. {ECO:0000269|PubMed:14749736, ECO:0000269|PubMed:15358861}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15358861}.
Top Pathways Protein processing in endoplasmic reticulum

Human NGLY1 full length protein - ab163212 from Abcam

Category Protein
Source Wheat germ
Species Human
ab163212 on a 12.5% SDS-PAGE stained with Coomassie Blue.

NGLY1 Blocking Peptide - LS-E8385 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human NGLY1 Protein - H00055768-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

NGLY1-Antibody-Center-Blocking-Peptide - BP6689c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

NGLY1-Antibody-N-term-Blocking-peptide - BP6689a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

NGLY1 - H00055768-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

NGLY1 - H00055768-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

NGLY1 fusion protein - Ag11729 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

NGLY1 fusion protein - ag11195 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human NGLY1, His-tagged - NGLY1-1288H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase(NGLY1) - CSB-YP853434HU CSB-EP853434HU CSB-BP853434HU CSB-MP853434HU from Cusabio

Category Peptide
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

NGLY1 (transcript variant 1) - TP303447 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
NGLY1

Peptide-N (4)-(N-acetyl-beta-glucosaminyl) asparagine amidase (NGLY1), Recombinant Protein - MBS1322957 from MyBioSource

Category Protein
Prices $1,455.00, $1,455.00, $1,680.00, $1,680.00, $2,470.00, $2,470.00, $2,910.00, $2,910.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

NGLY1 Recombinant Protein Antigen - NBP1-83792PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

NGLY1 Peptide, Human - M34GP10363H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Protein png-1 (png-1), Recombinant Protein - MBS1455054 from MyBioSource

Category Protein
Prices $1,150.00, $1,150.00, $1,380.00, $1,380.00, $1,840.00, $1,840.00, $2,300.00, $2,300.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Neurospora crassa

Protein png1 (png1), Recombinant Protein - MBS1307712 from MyBioSource

Category Protein
Prices $1,235.00, $1,235.00, $1,455.00, $1,455.00, $2,015.00, $2,015.00, $2,480.00, $2,480.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Aspergillus

Protein png1 (png1), Recombinant Protein - MBS1405273 from MyBioSource

Category Protein
Prices $1,235.00, $1,235.00, $1,455.00, $1,455.00, $2,010.00, $2,010.00, $2,470.00, $2,470.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Neosartorya

Protein PNG1 (PNG1), Recombinant Protein - MBS1394022 from MyBioSource

Category Protein
Prices $1,230.00, $1,230.00, $1,450.00, $1,450.00, $2,000.00, $2,000.00, $2,460.00, $2,460.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Wheat

Protein PNG1 (png1), Recombinant Protein - MBS1382614 from MyBioSource

Category Protein
Prices $1,220.00, $1,220.00, $1,440.00, $1,440.00, $1,975.00, $1,975.00, $2,440.00, $2,440.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Emericella

Protein PNG1 (PNG1), Recombinant Protein - MBS1327597 from MyBioSource

Category Protein
Prices $1,230.00, $1,230.00, $1,450.00, $1,450.00, $1,995.00, $1,995.00, $2,460.00, $2,460.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
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