NGLY1

Gene Symbol NGLY1
Entrez Gene 55768
Alt Symbol CDG1V, PNG1, PNGase
Species Human
Gene Type protein-coding
Description N-glycanase 1
Other Description hPNGase|peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase|peptide:N-glycanase
Swissprots Q6PJD8 Q96IV0 Q9BVR8 Q59FB1 Q9NR70 B4DJE9
Accessions EAW64363 EAW64364 EAW64365 EAW64366 Q96IV0 AB114414 AB114415 AB209549 BAD92786 AF250924 AAF74720 AK001867 BAA91950 AK022471 AK296047 BAG58811 AK310473 AL832748 BC000963 AAH00963 BC007226 AAH07226 BC017220 AAH17220 BQ017148 DC329733 DQ893509 ABM84435 DQ896501 ABM87500 XM_005265316 XP_005265373 XM_005265317 XP_005265374 XM_011533944 XP_011532246 XM_011533945 XP_011532247 XR_940470 XR_940471 NM_001145293 NP_001138765 NM_001145294 NP_001138766 NM_001145295 NP_001138767 NM_018297 NP_060767 NM_025105
Function Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. {ECO:0000269|PubMed:14749736, ECO:0000269|PubMed:15358861}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15358861}.
Top Pathways Protein processing in endoplasmic reticulum

PNGase CRISPR/Cas9 KO Plasmid (h) - sc-406323 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNGase HDR Plasmid (h) - sc-406323-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNGase Double Nickase Plasmid (h) - sc-406323-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNGase Double Nickase Plasmid (h2) - sc-406323-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNGase CRISPR Activation Plasmid (h) - sc-406323-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNGase CRISPR Activation Plasmid (h2) - sc-406323-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNGase Lentiviral Activation Particles (h) - sc-406323-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNGase Lentiviral Activation Particles (h2) - sc-406323-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNGase siRNA (h) - sc-78460 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PNGase shRNA Plasmid (h) - sc-78460-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PNGase shRNA (h) Lentiviral Particles - sc-78460-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU069651 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15274 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15274 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11962 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11962

NGLY1 siRNA (Human) - CRJ0905 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NGLY1 shRNA Plasmid (Human) - CHJ0905 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NGLY1 miRNA 3'UTR clone - MiUTR3H-11394 from Creative biogene

Species Reactivities Human

NGLY1 miRNA 3'UTR clone - MiUTR3H-11395 from Creative biogene

Species Reactivities Human

NGLY1 miRNA 3'UTR clone - MiUTR3H-11396 from Creative biogene

Species Reactivities Human

NGLY1 miRNA 3'UTR clone - MiUTR3H-11397 from Creative biogene

Species Reactivities Human
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